The Toxicology Investigators Consortium Case Registry-the 2015 Experience.
The Toxicology Investigators Consortium Case Registry-the 2015 Experience.
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毒理学调查者联盟病例登记——2015 年经验。
DOI：
10.1007/s13181-016-0580-6
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发表时间：
2016
期刊：
影响因子：
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通讯作者：
ToxicologyInvestigatorsConsortium
中科院分区：
文献类型：
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作者：
Farrugia,LynnA;Rhyee,SeanH;Campleman,SharanL;Ruha,Anne-Michelle;Weigand,Timothy;Wax,PaulM;Brent,Jeffrey;ToxicologyInvestigatorsConsortium
美国医学毒理学学会于2010年建立了毒理学研究者联盟（ToxIC）病例登记处。登记研究包含在参与研究中心进行的所有医学毒理学咨询。登记处自成立以来持续增长，截至2015年12月31日，共有43，099起案件。这是ToxIC登记处的第六份年度报告，总结了2015年新增的8115例病例。通过查询登记处确定了2015年1月1日至12月31日期间输入的所有病例。审查用于分析的具体数据包括人口统计学（年龄、种族、性别）、咨询来源、咨询原因、暴露所涉及的药物和药物类别、体征、症状、临床结果、死亡和治疗。截至2015年底，共有50个活动场所，包括101个独立的卫生保健设施; 51.2%的病例涉及女性。19至65岁的成年人占登记研究病例的大多数（64.2%）。高加索人种是最常报告的（55.6%）; 9.6%的病例被确定为西班牙裔。到目前为止，住院和急诊科转诊是最常见的转诊来源（92.9%）。故意药物暴露仍然是最常见的咨询原因，占病例的52.3%。在这些故意的药物暴露中，69%代表自我伤害的企图，其中85.6%是自杀企图。非阿片类镇痛药、镇静催眠药和抗抑郁药是2015年最常报告的药物类别。几乎三分之一的登记研究病例涉及诊断的毒性组（32.8%），其中镇静催眠毒性组是最常见的描述。在25.3%的病例中记录了显著的生命体征异常。登记研究中报告了98例死亡（1.2%）。4.3%的病例报告了药物不良反应。65.3%的病例进行了毒理学治疗，33.0%的病例接受了特异性解毒治疗。总体暴露特征和趋势与往年相似。虽然大多数病例需要治疗干预，但死亡病例很少。
The American College of Medical Toxicology established the Toxicology Investigators Consortium (ToxIC) Case Registry in 2010. The Registry contains all medical toxicology consultations performed at participating sites. The Registry has continued to grow since its inception, and as of December 31, 2015, contains 43,099 cases. This is the sixth annual report of the ToxIC Registry, summarizing the additional 8115 cases entered in 2015. Cases were identified by a query of the Registry for all cases entered between January 1 and December 31, 2015. Specific data reviewed for analysis included demographics (age, race, gender), source of consultation, reason for consultation, agents and agent classes involved in exposures, signs, symptoms, clinical findings, fatalities, and treatment. By the end of 2015, there were 50 active sites, consisting of 101 separate health-care facilities; 51.2 % of cases involved females. Adults between the ages of 19 and 65 made up the majority (64.2 %) of Registry cases. Caucasian race was the most commonly reported (55.6 %); 9.6 % of cases were identified as Hispanic ethnicity. Inpatient and emergency department referrals were by far the most common referral sources (92.9 %). Intentional pharmaceutical exposures remained the most frequent reason for consultation, making up 52.3 % of cases. Of these intentional pharmaceutical exposures, 69 % represented an attempt at self-harm, and 85.6 % of these were a suicide attempt. Nonopioid analgesics, sedative-hypnotics, and antidepressant agents were the most commonly reported agent classes in 2015. Almost one-third of Registry cases involved a diagnosed toxidrome (32.8 %), with a sedative-hypnotic toxidrome being the most frequently described. Significant vital sign abnormalities were recorded in 25.3 % of cases. There were 98 fatalities reported in the Registry (1.2 %). Adverse drug reactions were reported in 4.3 % of cases. Toxicological treatment was given in 65.3 % of cases, with 33.0 % receiving specific antidotal therapy. Exposure characteristics and trends overall were similar to prior years. While treatment interventions were required in the majority of cases, fatalities were rare.