Iron-catalyzed amidation of alkynyl bromides: a facile route for the preparation of ynamides.
Iron-catalyzed amidation of alkynyl bromides: a facile route for the preparation of ynamides.
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DOI：
10.1021/jo900595c
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发表时间：
2009-05
期刊：
影响因子：
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通讯作者：
B. Yao;Zunjun Liang;T. Niu;Yuhong Zhang
中科院分区：
文献类型：
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作者：
B. Yao;Zunjun Liang;T. Niu;Yuhong Zhang
本文介绍了一种简便、高产率地获得阿糖胞苷的方法。在20mol%的N，N ′-二甲基乙二胺（DMEDA）存在下，酰胺与溴代炔发生C-N偶联反应，得到了产物。
A facile route to obtain ynamides in high yields was described. The products were achieved through the iron-catalyzed C-N coupling reaction of amides with alkynyl bromides in the presence of 20 mol % of N,N'-dimethylethane-1,2-diamine (DMEDA).