Modulating the motor system by action observation after stroke.
Modulating the motor system by action observation after stroke.
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DOI：
10.1161/strokeaha.113.001105
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发表时间：
2013-08
期刊：
影响因子：
8.3
通讯作者：
Winstein CJ
中科院分区：
文献类型：
--
作者：
Garrison KA;Aziz-Zadeh L;Wong SW;Liew SL;Winstein CJ
最近的兴趣围绕着使用行动观察-观察另一个人执行运动任务-在中风康复，以促进运动恢复，通过从事类似的大脑区域的行动执行。这可能对行动能力有限的人特别有用。在这里，我们评估皮层运动活动在行动观察是如何受到中风和中风相关的运动缺陷。我们使用功能磁共振成像来比较观察右利手非残疾参与者和左半球中风前右利手的参与者的右和左手动作时的大脑活动。所有参与者在fMRI后都进行了相同的动作。非残疾参与者在观察使用左手做出的动作时显示出更大的双侧皮质运动活动，而中风参与者在观察使用右手（瘫痪）做出的动作时显示出更大的同病灶皮质运动活动（p<0.05，校正）。对于两组，动作处理都受到运动能力的调节：当观察运动得分较低的手时，皮质运动活动更大（p<0.05，校正）。此外，对于中风，同病灶活动的程度与病灶体积相关（p= 0.049），表明适应性可塑性的模式。我们发现，动作观察激活特定的运动计划在受损的运动回路中风后，这种活动是与运动能力，以执行相同的动作。在动作观察过程中的皮层运动活动可能与运动学习有关，也可能与中风康复中的运动再学习有关。
Much recent interest surrounds the use of action observation – observing another individual performing a motor task – in stroke rehabilitation, to promote motor recovery by engaging similar brain regions to action execution. This may be especially useful in individuals with limited mobility. Here we assess how cortical motor activity during action observation is affected by stroke and by stroke-related motor deficits. We used fMRI to compare brain activity during right and left hand action observation in right-handed non-disabled participants and participants who were right-handed prior to left hemisphere stroke. All participants performed the same actions after their fMRI. Non-disabled participants show greater bilateral cortical motor activity when observing actions made using the left hand, whereas participants with stroke show greater ipsilesional cortical motor activity when observing actions made using the right (paretic) hand (p<.05, corrected). For both groups, action processing is modulated by motor capability: cortical motor activity is greater when observing the hand with lower motor scores (p<.05, corrected). Further, for stroke, the extent of ipsilesional activity correlates with lesion volume (p=.049), in a pattern that suggests adaptive plasticity. We found that action observation activates specific motor plans in damaged motor circuits after stroke, and this activity is related to motor capability to perform the same actions. Cortical motor activity during action observation may be relevant to motor learning, and to motor relearning in stroke rehabilitation.