Methods for Providing Therapeutic Agents to Treat Damaged Spiral Ganglion Neurons
Methods for Providing Therapeutic Agents to Treat Damaged Spiral Ganglion Neurons
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DOI：
10.2174/1568007043337454
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发表时间：
2004-01-01
影响因子：
3
通讯作者：
Raz, Y.
中科院分区：
文献类型：
--
作者：
Bianchi, L. M.;Raz, Y.
感觉神经性听力损失的特征在于感觉毛细胞和/或相关神经纤维的损伤，是全世界听力障碍的主要原因。到目前为止，治疗选择是有限的，没有治愈受损的内耳细胞。由于内耳是容纳在颅骨深处的骨骼中的微小器官，因此进入内耳的途径是有限的，使得治疗剂的递送困难。近年来，科学家们研究了许多具有调节听觉神经元存活或恢复潜力的生长因子。与对可能恢复功能的分子的关注相一致的是开发新的递送方法的努力。研究人员一直在研究使用微型渗透泵、病毒载体和干细胞作为向内耳直接应用生长因子的手段。本文综述了最近的研究结果有关的分子，可能是有用的恢复受损的螺旋神经节神经元，以及各种传递系统的优点和缺点。
Sensorineural hearing loss, characterized by damage to sensory hair cells and/or associated nerve fibers is a leading cause of hearing disorders throughout the world. To date, treatment options are limited and there is no cure for damaged inner ear cells. Because the inner ear is a tiny organ housed in bone deep within the skull, access to the inner ear is limited, making delivery of therapeutic agents difficult. In recent years scientists have investigated a number of growth factors that have the potential to regulate survival or recovery of auditory neurons. Coinciding with the focus on molecules that may restore function are efforts to develop novel delivery methods. Researchers have been investigating the use of mini osmotic pumps, viral vectors and stem cells as a means of providing direct application of growth factors to the inner ear. This review summarizes recent findings regarding the molecules that may be useful for restoring damaged spiral ganglion neurons, as well as the advantages and disadvantages of various delivery systems.