Oxidation of an indole substrate by porphyrin iron(iii) superoxide: relevance to indoleamine and tryptophan 2,3-dioxygenases.
Oxidation of an indole substrate by porphyrin iron(iii) superoxide: relevance to indoleamine and tryptophan 2,3-dioxygenases.
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卟啉铁 (iii) 超氧化物对吲哚底物的氧化：与吲哚胺和色氨酸 2,3-双加氧酶的相关性。
DOI：
10.1039/c9cc10019a
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Goldberg,DavidP
中科院分区：
文献类型：
--
作者：
Sacramento,JirehJoyD;Goldberg,DavidP
FeIII(O2˙−)（TPP）与2,3-二甲基吲哚在−40℃下反应得到开环、双氧的N-（2-乙酰苯基）-乙酰胺产物。通过低温紫外可见光谱和1H核磁共振光谱对反应进行了现场监测。这项工作表明，离散铁（III）（超氧）卟啉能够进行吲哚氧化，正如色氨酸和吲哚胺2,3-双加氧酶所提出的那样。
Reaction of FeIII(O2˙−)(TPP) with 2,3-dimethylindole at −40 °C gives the ring-opened, dioxygenated N-(2-acetyl-phenyl)-acetamide product. The reaction was monitored in situ by low-temperature UV-vis and 1H NMR spectroscopies. This work demonstrates that a discrete iron(III)(superoxo) porphyrin is competent to carry out indole oxidation, as proposed for the tryptophan and indoleamine 2,3-dioxygenases.