Prediction of Colorectal Cancer Relapse and Prognosis by Tissue mRNA Levels of NDRG2
Prediction of Colorectal Cancer Relapse and Prognosis by Tissue mRNA Levels of NDRG2
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通过组织 NDRG2 mRNA 水平预测结直肠癌复发和预后
DOI：
10.1158/1535-7163.mct-10-0614
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发表时间：
2011-01-01
影响因子：
5.7
通讯作者：
Zhang, Jian
中科院分区：
文献类型：
--
作者：
Chu, Dake;Zhang, Zixi;Zhang, Jian
NDRG2(N-Myc下游调节基因2)在结直肠癌中异常表达，并与肿瘤分化程度有关。在本研究中，我们研究了NDRG2基因在原发结直肠癌中的表达水平之间的关系，以确定NDRG2基因表达水平是否可以预测复发和生存。以医院为基础的226名结直肠癌患者的研究队列参与了这项研究。实时荧光定量聚合酶链式反应检测NDRG2基因的表达水平。分析NDRG2基因表达与肿瘤临床病理特征、无瘤生存期和总生存期的关系。肿瘤组织中NDRG2基因的表达显著降低。NDRG2mRNA的表达与肿瘤分化程度(P<；0.001)、淋巴结转移(P<；0.001)和肿瘤转移分期(P<；0.001)显著相关。NDRG2基因表达下调患者的无瘤生存期和总生存期明显短于NDRG2基因表达下调患者。在多因素分析中，NDRG2基因表达水平是影响结直肠癌患者无病生存和总体生存的独立预后因素。本研究首次提供证据表明，原发人类结直肠癌中NDRG2基因表达降低可能是复发和预后的一个强大的、独立的预测因子。摩尔癌症治疗；10(1)；47-56。©2011 AACR。
NDRG2 (N-Myc downstream-regulated gene 2) is aberrantly expressed in colorectal cancer (CRC) and related to tumor differentiation status. In the present study, we investigated the association between NDRG2 mRNA levels in primary CRC to determine whether levels of NDRG2 mRNA could predict relapse and survival. A hospital-based study cohort of 226 CRC patients was involved in the study. NDRG2 mRNA levels were determined by real-time PCR. Correlations of NDRG2 mRNA expression with tumor clinicopathologic features, disease-free survival, and overall survival of the patients were studied. Significant decreased expression of NDRG2 mRNA was detected in tumor specimens. NDRG2 mRNA expression significantly correlated with differentiation status (P < 0.001), lymph node metastasis (P < 0.001), and tumor node metastasis stage (P < 0.001). Patients with reduced level of NDRG2 mRNA had a statistically significantly shorter disease-free survival and overall survival duration than patients with preserved expression of NDRG2 mRNA. In multivariate analysis, NDRG2 mRNA level was found to be an independent prognostic factor for both disease-free survival and overall survival of CRC patients. The present research provided the first evidence that decreased NDRG2 mRNA expression in primary human CRC might be a powerful, independent predictor of recurrence and outcome. Mol Cancer Ther; 10(1); 47–56. ©2011 AACR.