Interferon-β signaling is enhanced in patients with insufficient coronary collateral artery development and inhibits arteriogenesis in mice
Interferon-β signaling is enhanced in patients with insufficient coronary collateral artery development and inhibits arteriogenesis in mice
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DOI：
10.1161/circresaha.108.171827
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发表时间：
2008-05-23
影响因子：
20.1
通讯作者：
van Royen, Niels
中科院分区：
文献类型：
--
作者：
Schirmer, Stephan H.;Fledderus, Joost O.;van Royen, Niels
尽管有很好的实验方法，但迄今为止刺激患者侧支动脉生长并不成功。循环单核细胞参与侧支动脉的生长，这一过程也称为动脉生成。患者对动脉阻塞的天然动脉生成反应表现出很大的异质性。我们假设，循环细胞转录组将提供机制的见解和新的治疗策略，以刺激动脉生成。测量了45例单支冠状动脉疾病患者的侧支血流指数，将侧支反应者（侧支血流指数，> 0.21）和无反应者（侧支血流指数，
Stimulation of collateral artery growth in patients has been hitherto unsuccessful, despite promising experimental approaches. Circulating monocytes are involved in the growth of collateral arteries, a process also referred to as arteriogenesis. Patients show a large heterogeneity in their natural arteriogenic response on arterial obstruction. We hypothesized that circulating cell transcriptomes would provide mechanistic insights and new therapeutic strategies to stimulate arteriogenesis. Collateral flow index was measured in 45 patients with single-vessel coronary artery disease, separating collateral responders (collateral flow index, > 0.21) and nonresponders (collateral flow index,