Generation of simian-tropic HIV-1 by restriction factor evasion
Generation of simian-tropic HIV-1 by restriction factor evasion
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DOI：
10.1126/science.1130994
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发表时间：
2006-10-06
期刊：
影响因子：
56.9
通讯作者：
Bieniasz, Paul D.
中科院分区：
文献类型：
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作者：
Hatziioannou, Theodora;Princiotta, Michael;Bieniasz, Paul D.
由于HIV-1不感染大多数非人灵长类动物，人类HIV感染和AIDS的动物模型主要包括用相关的猿猴免疫缺陷病毒（SIVMAC）实验感染猕猴。然而，这种模型的有用性受到SIVMAC和HIV-1之间的实质性差异的限制。我们衍生出一种基于HIV-1的病毒，该病毒仅包含一小部分SIVMAC，但在转化的和原代恒河猴T细胞中均能稳健复制。嗜猴HIV-1（stHIV-1）的推导对于了解灵长类慢病毒人畜共患疾病具有重要意义，并且应该能够开发改进的动物模型来研究艾滋病以及评估疫苗和治疗方法。
Because HIV-1 does not infect most nonhuman primates, animal modeling of human HIV infection and AIDS has primarily consisted of experimentally infecting macaques with related simian immunodeficiency viruses (SIVMAC). However, the usefulness of such models is limited by the substantial divergence between SIVMAC and HIV-1. We derived an HIV-1‐based virus that includes only small portions of SIVMAC yet replicates robustly in both transformed and primary rhesus macaque T cells. Derivation of simian-tropic HIV-1 (stHIV-1) has important implications for understanding primate lentivirus zoonosis and should allow the development of improved animal models for studies of AIDS and the evaluation of vaccines and treatments.