ANXA2 expression in African American triple-negative breast cancer patients
ANXA2 expression in African American triple-negative breast cancer patients
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DOI：
10.1007/s10549-018-5030-5
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发表时间：
2019-02-01
影响因子：
3.8
通讯作者：
Vishwanatha, Jamboor K.
中科院分区：
文献类型：
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作者：
Gibbs, Lee D.;Chaudhary, Pankaj;Vishwanatha, Jamboor K.
PurposeOur aim is to determine the role of Annexin A2（AnxA2），which we have previously found to contribute to aggressiveness of TNBC，with AA TNBC patients and clinical outcome.MethodsWe analyzed TCGA breast cancer database（n = 1098）to observe AnxA2 expression within breast cancer subtypes and is correlated with overall survival.此外，我们检查了乳腺组织标本（n = 119）通过显色原位杂交（CISH）和标本进行了独立的评分由两名病理学家在一个盲study.ResultsIn我们的TCGA分析，AnxA2的高表达与TNBC患者的生存率差。AnxA2基因表达与其他乳腺癌亚型的生存率不相关。与雌激素受体和/或孕激素受体阳性、人表皮生长因子阳性和非恶性组织相比，TNBC的AnxA2平均CISH强度评分（CISH评分= 0，无表达至3，高表达）显著更高。此外，AnxA2平均得分在AA TNBC患者（CISH平均得分= 2.450.3266）中显著高于白人TNBC患者（CISH平均得分= 1.1 +/-0.4069）。
PurposeOur aim was to determine the role of Annexin A2 (AnxA2), which we have previously found to contribute to the aggressiveness of TNBC, with AA TNBC patients and clinical outcome.MethodsWe analyzed TCGA breast cancer database (n=1098) to observe AnxA2 expression within breast cancer subtypes and is correlation with overall survival. Further, we examined breast tissue specimens (n=119) through chromogenic in situ hybridization (CISH) and specimen were scored independently by two pathologists in a blinded study.ResultsIn our TCGA analysis, high expression of AnxA2 was correlated with poor survival in patients with TNBC. AnxA2 gene expression was not correlated with poor survival in other breast cancer subtypes. AnxA2 average CISH intensity score (CISH score=0, null expression to 3, high expression) for TNBC was significantly higher in comparison to estrogen receptor and/or progesterone receptor positive, human epidermal growth factor positive, and non-malignant tissues. Furthermore, AnxA2 average score was significantly higher in AA TNBC patients (CISH average score=2.450.3266) in comparison to Caucasian TNBC patients (CISH average score=1.1 +/- 0.4069).Conclusion AnxA2 is overexpressed in TNBC, implicating AnxA2 as a contributor to the aggressive biology of TNBC in AA women.