AKT and ERK1/2 signaling in intrahepatic cholanglocarcinoma
AKT and ERK1/2 signaling in intrahepatic cholanglocarcinoma
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DOI：
10.3748/wjg.13.6470
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发表时间：
2007-12-28
影响因子：
4.3
通讯作者：
Baba, H. A.
中科院分区：
文献类型：
--
作者：
Schmitz, K. J.;Lang, H.;Baba, H. A.
肝内胆管细胞癌(ICC)是起源于胆管细胞的肿瘤，可发生在胆道树的任何层面。手术切除是目前治疗这种高度侵袭性癌症的首选方法。但5年生存率仍较低，复发率较高。由于肝内生长，相当大比例的患者患有晚期疾病，不适合进行根治性手术或移植。现有的姑息治疗方案益处有限，需要新的治疗方案。本文综述了磷脂酰肌醇3-激酶(PI3K)/AKT和细胞外调节激酶(ERK)信号通路在ICC中的作用，并提供了有关这些蛋白激酶预后价值的新数据。最后，我们以这些信号通路为靶点，讨论未来的治疗选择。(C)2007年WJG。版权所有。
Intrahepatic cholangiocarcinomas (ICC) are neoplasms that originate from cholangiocytes and can occur at any level of the biliary tree. Surgical resection is the current therapy of choice for this highly aggressive cancer. However, the 5-year survival still is poor, with high recurrence rates. Due to the intrahepatic growth a significant proportion of patients present with advanced disease and are not candidates for curative surgery or transplantation. The existing palliative options are of limited benefit and there is a great necessity for novel therapeutic options. In this article we review the role of the phosphoinositide 3-kinase(PI3K)/ AKT and extracellular regulated kinase (ERK) signaling pathways in ICC and present new data on the prognostic value of these protein kinases. Finally, we discuss future upcoming therapeutic options based on targeting these signaling pathways. (C) 2007 WJG. All rights reserved.