Brown fat as a therapy for obesity and diabetes.
Brown fat as a therapy for obesity and diabetes.
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DOI：
10.1097/med.0b013e328337a81f
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发表时间：
2010-04
期刊：
影响因子：
--
通讯作者：
Kahn CR
中科院分区：
文献类型：
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作者：
Cypess AM;Kahn CR
人体脂肪由白色和棕色脂肪组织（WAT和BAT）组成。虽然大多数脂肪是能量储存的WAT，但即使是少量BAT的产热能力也使其成为通过能量消耗诱导减肥的有吸引力的治疗目标。本综述评估了最近发现的功能性BAT在成年人中的鉴定及其作为肥胖和糖尿病治疗的潜力。在过去的一年里，几个独立的研究小组使用了正电子发射断层扫描和计算机断层扫描（PET/CT）成像，免疫组织化学以及基因和蛋白质表达测定的组合，以最终证明成年人具有功能性BAT。这是在基础研究的背景下发生的，这些研究定义了BAT的起源、其转录调控的新成分以及激素在刺激BAT生长和分化中的作用。成年人具有功能性BAT，这是减肥和抗糖尿病治疗的新目标，重点是增加能量消耗。未来的研究将完善用于测量BAT质量和活性的方法，扩大我们对BAT调控关键控制点的了解，并专注于测试增加BAT产热并有助于实现持久减肥和改善代谢状况的药理学药物。
Human fat consists of white and brown adipose tissue (WAT and BAT). Though most fat is energy-storing WAT, the thermogenic capacity of even small amounts of BAT makes it an attractive therapeutic target for inducing weight loss through energy expenditure. This review evaluates the recent discoveries regarding the identification of functional BAT in adult humans and its potential as a therapy for obesity and diabetes. Over the past year, several independent research teams used a combination of positron-emission tomography and computed tomography (PET/CT) imaging, immunohistochemistry, and gene and protein expression assays to prove conclusively that adult humans have functional BAT. This has occurred against a backdrop of basic studies defining the origins of BAT, new components of its transcriptional regulation, and the role of hormones in stimulation of BAT growth and differentiation. Adult humans have functional BAT, a new target for antiobesity and antidiabetes therapies focusing on increasing energy expenditure. Future studies will refine the methodologies used to measure BAT mass and activity, expand our knowledge of critical-control points in BAT regulation, and focus on testing pharmacological agents that increase BAT thermogenesis and help achieve long-lasting weight loss and an improved metabolic profile.