Frontal lobe phosphorus metabolism and neuropsychological function in aging and in Alzheimer's disease.
Frontal lobe phosphorus metabolism and neuropsychological function in aging and in Alzheimer's disease.
复制标题
额叶磷代谢和衰老和阿尔茨海默病中的神经心理学功能。
DOI：
10.1002/ana.410380211
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发表时间：
1995
期刊：
影响因子：
--
通讯作者：
Markesberry,WR
中科院分区：
文献类型：
--
作者：
Smith,CD;Pettigrew,LC;Avison,MJ;Kirsch,JE;Tinkhtman,AJ;Schmitt,FA;Wermeling,DP;Wekstein,DR;Markesberry,WR
对17例阿尔茨海默病（AD）、8例老年对照（EC）和17例青年对照（YC）进行了额叶31 P磁共振波谱分析。AD组磷酸肌酸/无机磷酸盐（PCr/Pi）比值（2.32 ± 0.26 SD）显著低于EC组（2.65 ± 0.41 SD）。在AD患者中，观察到PCr/Pi比值与痴呆评定量表之间存在相关性（r=-0.50，p = 0.04）。在AD组（r= 0.67，p0.003）和YC组（r= 0.63，p0.006）中均观察到PCr/Pi比值与年龄呈显著正相关，但提示在AD中解释该比值时应谨慎。我们在任何其他光谱测量中没有发现AD、EC或YC之间的差异。在AD脑中观察到磷酸单酯/磷酸二酯比率（PME/PDE）的显著性别差异。女性的PME/PDE比率低于男性。
31P Magnetic resonance spectroscopy of the frontal lobe was performed in 17 patients with Alzheimer's disease (AD), 8 elderly controls (EC), and 17 young controls (YC). The phosphocreatine/inorganic phosphate (PCr/Pi) ratio in AD (2.32 ± 0.26 SD) was significantly lower than in EC (2.65 ± 0.41). In AD patients, a correlation was observed between the PCr/Pi ratio and the dementia rating scale (r= −0.50,p= 0.04). A significant positive correlation between PCr/Pi ratio and age was observed in both AD (r= 0.67,p0.003) and YC (r= 0.63,p0.006) groups, however, suggesting caution in interpretation of this ratio in AD. We did not find differences between AD, EC, or YC in any other spectroscopic measure. A significant sex difference in the phosphomonoester/phosphodiester ratio (PME/PDE) ratio was observed in AD brain. Females had a lower PME/PDE ratio than males.