Resting state Functional Connectivity of the Anterior Cingulate Cortex in Veterans With and Without Post-traumatic Stress Disorder
Resting state Functional Connectivity of the Anterior Cingulate Cortex in Veterans With and Without Post-traumatic Stress Disorder
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DOI：
10.1002/hbm.22615
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发表时间：
2015-01-01
影响因子：
4.8
通讯作者：
Geuze, Elbert
中科院分区：
文献类型：
--
作者：
Kennis, Mitzy;Rademaker, Arthur R.;Geuze, Elbert
创伤后应激障碍（PTSD）是一种焦虑症，与包括前扣带皮层（ACC）在内的几个大脑区域的结构和功能改变有关。在这里，我们研究静息状态下的功能连接的ACC分区在PTSD，使用种子为基础的方法。静息状态的磁共振图像从男性退伍军人（n=31）和没有（n=25）创伤后应激障碍，和健康的男性平民控制（n=25）。与健康对照组相比，患有和不患有PTSD的退伍军人（战斗对照组）的尾侧ACC和中央前回之间以及膝周ACC和上级内侧回和颞中回之间的功能连接减少。与PTSD患者和健康平民对照组相比，战斗对照组的喙侧ACC和中央前回/额中回之间的连接性增加。静息状态下膝周前扣带网络的功能连接差异表明，退伍军人不同于健康对照，可能是由于军事训练，部署，和/或创伤暴露。此外，战斗控制中的具体变化可能与弹性有关。这些结果强调了在研究PTSD时区分创伤暴露（战斗）对照组和健康平民对照组的重要性。《脑地图》，36：99-109，2015年。(c)2014 Wiley Periodicals，Inc.
Post-traumatic stress disorder (PTSD) is an anxiety disorder that is associated with structural and functional alterations in several brain areas, including the anterior cingulate cortex (ACC). Here, we examine resting state functional connectivity of ACC subdivisions in PTSD, using a seed-based approach. Resting state magnetic resonance images were obtained from male veterans with (n=31) and without (n=25) PTSD, and healthy male civilian controls (n=25). Veterans with and without PTSD (combat controls) had reduced functional connectivity compared to healthy controls between the caudal ACC and the precentral gyrus, and between the perigenual ACC and the superior medial gyrus and middle temporal gyrus. Combat controls had increased connectivity between the rostral ACC and precentral/middle frontal gyrus compared to PTSD patients and healthy civilian controls. The resting state functional connectivity differences in the perigenual ACC network reported here indicate that veterans differ from healthy controls, potentially due to military training, deployment, and/or trauma exposure. In addition, specific alterations in the combat controls may potentially be related to resilience. These results underline the importance of distinguishing trauma-exposed (combat) controls from healthy civilian controls when studying PTSD. Hum Brain Mapp, 36:99-109, 2015. (c) 2014 Wiley Periodicals, Inc.