Ultrastructural features of atrial peptide secretion.
Ultrastructural features of atrial peptide secretion.
复制标题
心房肽分泌的超微结构特征。
DOI：
10.1152/ajpheart.1986.251.2.h340
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发表时间：
1986
期刊：
影响因子：
--
通讯作者：
Upshaw-Earley,J
中科院分区：
文献类型：
--
作者：
Page,E;Goings,GE;Power,B;Upshaw-Earley,J
The ultrastructural bases of exocytotic extrusion of atrial peptides were reexamined in electron micrographs of thin-sectioned or freeze-fractured mouse atria. Exocytotic extrusion was demonstrated in both thin-sectioned and freeze-fractured atrial myocytes. Ultrastructural evidence suggested that the necks of plasmalemmal caveolae may constitute preformed pathways for extrusion of secretion from granules fusing with caveolae. Multiple subsarcolemmal foci with peripheral Golgi cisterns and accumulations of granules, indicating peripheral processing of secretory proteins, were striking features of mouse and rat atria, and were present but rare in sheep and dog atria. Conspicuous focal ellipsoidal deposits, a new structure, approximately 1.6-4.6 micron long and approximately 0.8-1.8 micron wide, consisting of amorphous cytoplasmic material that is penetrated peripherally by tubules connecting with secretion-containing "multivesicular bodies," were present in some mouse atrial myocytes, but were absent in myocytes of mouse ventricle and rat, dog, and sheep atria.
