Mental navigation along memorized routes activates the hippocampus, precuneus, and insula
Mental navigation along memorized routes activates the hippocampus, precuneus, and insula
复制标题
DOI：
10.1097/00001756-199702100-00032
复制
发表时间：
1997-02-10
期刊：
影响因子：
1.7
通讯作者：
Denis, M
中科院分区：
文献类型：
--
作者：
Ghaem, O;Mellet, E;Denis, M
应用正电子发射断层扫描技术，对5名正常志愿者的心理模拟路径（MSR）进行了功能解剖学研究。当受试者在先前通过实际导航学习的路线的地标之间进行心理导航时，测量标准化的局部脑血流量。这项任务进行了对比与静态视觉图像的地标（VIL）和沉默的休息。MSR似乎是由两个不同的网络subserved：一个非特异性的记忆网络，包括海马区的后部和中部，背外侧前额叶皮层和后扣带，和一个特定的心理导航网络，包括左楔前叶，海马区的内侧部分。
POSITRON emission tomography was used to investigate the functional anatomy of mental simulation of routes (MSR) in five normal volunteers. Normalized regional cerebral blood flow was measured while subjects mentally navigated between landmarks of a route which had been previously learned by actual navigation. This task was contrasted with both static visual imagery of landmarks (VIL) and silent Rest. MSR appears to be subserved by two distinct networks: a non-specific memory network including the posterior and middle parts of the hippocampal regions, the dorsolateral prefrontal cortex and the posterior cingulum, and a specific mental navigation network, comprising the left precuneus, insula and medial part of the hippocampal regions.