Genetic mutual relationship between PTEN and p53 in gastric cancer
Genetic mutual relationship between PTEN and p53 in gastric cancer
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DOI：
10.1016/j.canlet.2004.12.006
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发表时间：
2005-09-08
期刊：
影响因子：
9.7
通讯作者：
Maehara, Y
中科院分区：
文献类型：
--
作者：
Oki, E;Tokunaga, E;Maehara, Y
PTEN（编码磷酸盐和张力蛋白同源物）和p53都是已知的癌症抑制基因，并且它们被认为在各种类型的癌症中频繁发生基因突变和杂合性丢失（洛）。本研究检测了113例胃癌组织中抑癌基因PTEN的p53突变和洛缺失。在p53基因正常和p53基因突变的患者中，PTEN的洛丢失率分别为11.1%和46.2%。本研究结果提示，在p53基因突变的胃癌中，PTEN的洛丢失率较高，提示二者在胃癌的发生发展中具有互补作用。(C)2004爱思唯尔爱尔兰有限公司保留所有权利。
Both PTEN (encoding phosphate and tensin homologue) and p53 are known as cancer suppressor genes, and they are assumed that their gene mutations and loss of heterozygosity (LOH) occur frequently in various types of carcinoma. In the present study, we investigated both the p53 mutation and LOH of PTEN in 113 gastric cancer patients. We observed the LOH of PTEN in 11.1% of the patients with normal p53s and 46.2% of the patients with p53 gene mutations. The result that LOH of PTEN was frequently observed in the cases with p53 gene mutations and other data in this study suggested that both PTEN and p53 have complimentary roles in gastric carcinoma development. (C) 2004 Elsevier Ireland Ltd. All rights reserved.