Enhanced production of farnesol by Candida albicans treated with four azoles
Enhanced production of farnesol by Candida albicans treated with four azoles
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DOI：
10.1128/aac.48.6.2305-2307.2004
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发表时间：
2004-06-01
影响因子：
4.9
通讯作者：
Nickerson, KW
中科院分区：
文献类型：
--
作者：
Hornby, JM;Nickerson, KW
二态真菌白色念珠菌分泌金合糖醇，它是由甾醇生物合成中间体金合糖基焦磷酸酶促产生的。四种含唑类抗真菌药物，环康唑、酮康唑、咪康唑和克霉唑，对白色念珠菌的抑制作用可导致法尼醇产量升高（10- 45倍）。此外，法尼醇生产发生在实验室菌株和临床分离株（J. M. Hornby等人，苹果公司）。环绕。微生物学杂志。67:2982-2992,2001)。
The dimorphic fungus Candida albicans excretes farnesol, which is produced enzymatically from the sterol biosynthetic intermediate farnesyl pyrophosphate. Inhibition of C. albicans by four azole antifungals, Huconazole, ketoconazole, miconazole, and clotrimazole, caused elevated farnesol production (10- to 45-fold). Furthermore, farnesol production occurs in both laboratory strains and clinical isolates (J. M. Hornby et al., Appl. Environ. Microbiol. 67:2982-2992, 2001) of C. albicans.