Isolation and chromosomal mapping of a mouse homolog of the Batten disease gene CLN3.
Isolation and chromosomal mapping of a mouse homolog of the Batten disease gene CLN3.
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巴顿病基因 CLN3 的小鼠同源物的分离和染色体作图。
DOI：
10.1006/geno.1996.0410
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发表时间：
1996
期刊：
影响因子：
--
通讯作者：
Lerner,TJ
中科院分区：
文献类型：
--
作者：
Lee,RL;Johnson,KR;Lerner,TJ
我们描述了巴顿病基因 CLN3 的小鼠同源物的分离和染色体作图。与人类对应物一样，小鼠 cDNA 包含一个 1314 bp 的开放阅读框，编码 438 个氨基酸的预测蛋白质产物。小鼠和人类编码区在核酸和氨基酸水平上分别有 82% 和 85% 相同。小鼠基因映射到远端 7 号染色体，该区域包含与人类染色体 16p12 上同源的基因，其中 CLN3 映射。小鼠CLN3同源物的分离将有助于创建Batten病小鼠模型。
We describe the isolation and chromosomal mapping of a mouse homolog of the Batten disease gene,CLN3.Like its human counterpart, the mouse cDNA contains an open reading frame of 1314 bp encoding a predicted protein product of 438 amino acids. The mouse and human coding regions are 82 and 85% identical at the nucleic acid and amino acid levels, respectively. The mouse gene maps to distal Chromosome 7, in a region containing genes whose homologs are on human chromosome 16p12, whereCLN3maps. Isolation of a mouseCLN3homolog will facilitate the creation of a mouse model of Batten disease.