Working together: interactions between vaccine antigens and adjuvants.
Working together: interactions between vaccine antigens and adjuvants.
复制标题
DOI：
10.1177/2051013613480144
复制
发表时间：
2013-05-01
期刊：
影响因子：
--
通讯作者：
Vedvick, Thomas S
中科院分区：
文献类型：
--
作者：
Fox, Christopher B;Kramer, Ryan M;Vedvick, Thomas S
含有佐剂的疫苗的开发有可能增强抗体和细胞免疫反应，扩大对异质病原体菌株的保护性免疫，使抗原剂量节省，并促进免疫功能低下人群的疗效。然而，在已发表的文献中，抗原和佐剂成分之间的结构相互作用往往没有考虑到。抗原和佐剂制剂之间的相互作用应该很好地表征，以实现最佳的疫苗稳定性和有效性。本文通过总结广泛使用的佐剂配方平台（如铝盐、乳剂、脂质囊泡和聚合物基颗粒）的研究结果，重点介绍了表征抗原-佐剂相互作用的重要性。重点放在抗原-佐剂关联的物理化学基础和表征它们的适当分析工具上，并讨论这些相互作用对疫苗效力的影响。
The development of vaccines containing adjuvants has the potential to enhance antibody and cellular immune responses, broaden protective immunity against heterogeneous pathogen strains, enable antigen dose sparing, and facilitate efficacy in immunocompromised populations. Nevertheless, the structural interplay between antigen and adjuvant components is often not taken into account in the published literature. Interactions between antigen and adjuvant formulations should be well characterized to enable optimum vaccine stability and efficacy. This review focuses on the importance of characterizing antigen-adjuvant interactions by summarizing findings involving widely used adjuvant formulation platforms, such as aluminum salts, emulsions, lipid vesicles, and polymer-based particles. Emphasis is placed on the physicochemical basis of antigen-adjuvant associations and the appropriate analytical tools for their characterization, as well as discussing the effects of these interactions on vaccine potency.