Bringing new life to damaged bone: The importance of angiogenesis in bone repair and regeneration
Bringing new life to damaged bone: The importance of angiogenesis in bone repair and regeneration
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DOI：
10.1016/j.bone.2014.09.017
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发表时间：
2015-01-01
期刊：
影响因子：
4.1
通讯作者：
Carmeliet, Geert
中科院分区：
文献类型：
--
作者：
Stegen, Steve;van Gastel, Nick;Carmeliet, Geert
骨具有独特的愈合能力而不形成纤维性瘢痕，这可能是因为控制骨愈合的几种细胞和分子过程重演了骨骼发育期间的事件。骨愈合的一个关键组成部分是骨折骨痂中血管的及时出现。血管生成，即从原有血管形成新血管，在骨折后通过大量血管生成生长因子的局部产生来刺激。骨折脉管系统不仅提供氧气和营养物质，而且还提供能够分化成成骨细胞的干细胞，并且在后期阶段还提供矿化所需的离子。本文综述了骨细胞对血管生成的调控及其在骨愈合过程中的重要性和在骨组织工程治疗中的应用。这篇文章是题为“干细胞和骨骼”的特刊的一部分。(C)2014爱思唯尔公司All rights reserved.
Bone has the unique capacity to heal without the formation of a fibrous scar, likely because several of the cellular and molecular processes governing bone healing recapitulate the events during skeletal development. A critical component in bone healing is the timely appearance of blood vessels in the fracture callus. Angiogenesis, the formation of new blood vessels from pre-existing ones, is stimulated after fracture by the local production of numerous angiogenic growth factors. The fracture vasculature not only supplies oxygen and nutrients, but also stem cells able to differentiate into osteoblasts and in a later phase also the ions necessary for mineralization. This review provides a concise report of the regulation of angiogenesis by bone cells, its importance during bone healing and its possible therapeutic applications in bone tissue engineering. This article is part of a Special Issue entitled "Stem Cells and Bone". (C) 2014 Elsevier Inc. All rights reserved.