Linking immunity and sickness-induced sleep.
Linking immunity and sickness-induced sleep.
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将免疫力与疾病引起的睡眠联系起来。
DOI：
10.1126/science.aaw2113
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发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Prober,DavidA
中科院分区：
文献类型：
--
作者：
Oikonomou,Grigorios;Prober,DavidA
我们都熟悉在生病时所经历的困倦。更少人意识到的是，睡眠需求的增加是由我们自己的免疫和神经系统释放信号分子引起的，而不是由感染性病原体本身引起的。事实上，对于病毒或细菌的传播，如果我们生病时外出走动，而不是睡觉，那会好得多。在本期的第509页，Todaet al.(2)通过识别NEMURI(NURI)揭示了睡眠和免疫之间相互作用的另一个方面，NEMURI是一种由果蝇黑腹果蝇产生的抗菌肽(AMP)，也具有促进睡眠的特性。由于人类合成了100多种不同的AMP，这项工作可能会对人类疾病期间睡眠和免疫之间的相互作用产生影响。
We are all familiar with the sleepiness experienced during sickness. What is less often appreciated is that this increased need for sleep is caused by the release of signaling molecules by our own immune and nervous systems, and not by the infectious agents themselves (1). Indeed, for the spread of a virus or a bacterium, it would be much better if we were out and about when sick, instead of sleeping. On page 509 of this issue, Todaet al.(2) reveal another facet of the interplay between sleep and immunity by identifying NEMURI (NUR), an antimicrobial peptide (AMP) produced by the fruit flyDrosophila melanogasterthat also has sleep-promoting properties. Because humans synthesize more than 100 different AMPs (3), this work could have implications for interactions between sleep and immunity during human disease.