Total body aromatization in postmenopausal breast cancer patients is strongly correlated to plasma leptin levels
Total body aromatization in postmenopausal breast cancer patients is strongly correlated to plasma leptin levels
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DOI：
10.1016/j.jsbmb.2006.09.040
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发表时间：
2007-04-01
影响因子：
4.1
通讯作者：
Lonning, Per Eystein
中科院分区：
文献类型：
--
作者：
Geisler, Juergen;Haynes, Ben;Lonning, Per Eystein
脂肪细胞因子瘦素最近已被证明通过启动子II和I.3使用AP-1基序增强芳香酶的表达。因此，我们评估了绝经后乳腺癌患者血浆瘦素浓度与全身芳构化（TBA）以及血浆雌酮（E-1）、雌二醇（E-2）和硫酸雌酮（E1 S）水平之间的相关性。22名绝经后转移性乳腺癌女性参与了体内全身芳构化（TBA）测量的示踪剂研究。此外，血浆雌激素和瘦素测量的血液样本可从另外22名乳腺癌患者和114名健康绝经后妇女参与乳房X线检查筛查计划。TBA值变化范围为1.46 - 4.72%，而血浆瘦素水平在同一组患者中变化范围为1.83 - 95.51 ng/ml。所有血浆雌激素水平均在绝经后妇女预期的正常范围内。我们发现治疗前瘦素水平与TBA显著相关（r（s）0.452，P=0.01）。相反，在同一组患者中，TBA的基础水平与体重指数（BMI）无关。在乳腺癌组（n=44）和健康绝经后妇女组（雌二醇，r（s）0.363，P = 0.007）中，血浆瘦素水平与血浆雌二醇（r（s）0.659，P = 0.007）和硫酸雌酮（r（s）0.562，P=0.01）相关。
The adipocytokine leptin has recently been shown to enhance the expression of aromatase via promoter II and I.3 using an AP-1 motif. Thus, we evaluated the correlation between plasma leptin concentrations and total body aromatization (TBA) as well as plasma levels of estrone (E-1), estradiol (E-2) and estrone sulfate (E1S) in postmenopausal breast cancer patients. Twenty-two postmenopausal women with metastatic breast cancer, participating in tracer studies for the measurement of total body aromatization (TBA) in vivo, were available. In addition, blood samples for plasma estrogens and leptin measurements were available from another 22 breast cancer patients and 114 healthy postmenopausal women participating in the mammography-screening program. Values for TBA varied from 1.46 to 4.72% while plasma leptin levels ranged from 1.83 to 95.51 ng/ml in the same group of patients. All plasma estrogen levels were in the normal range expected for postmenopausal women. We found a significant correlation between pretreatment leptin levels and TBA (r(s) 0.452, P=0.01). In contrast, basal levels of TBA did not correlate to body mass index (BMI) in the same group of patients. Plasma leptin levels correlated to plasma levels of estradiol (r(s) 0.659, P = 0.007), and estrone sulfate (r(s) 0.562, P=0.01) in the group of breast cancer patients (n=44) as well as in the group of healthy postmenopausal women (estradiol, r(s) 0.363, P