In Vivo 39K MR Imaging of Human Muscle and Brain
In Vivo 39K MR Imaging of Human Muscle and Brain
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DOI：
10.1148/radiol.13130757
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发表时间：
2013-11-01
期刊：
影响因子：
19.7
通讯作者：
Nagel, Armin M.
中科院分区：
文献类型：
--
作者：
Umathum, Reiner;Roesler, Manuela B.;Nagel, Armin M.
目的：应用7-T磁共振成像系统进行39钾(K-39)磁共振成像，并评价其用于人体肌肉和脑活体成像的可行性。材料和方法：经海德堡大学伦理审查委员会批准，对3名健康志愿者进行检查。所有志愿者都获得了书面知情同意。由于现有的7-T磁共振成像系统不支持K-39，因此开发了一种频率转换方案并将其连接到成像单元。锂7的标准X核频率(115 MHz)在7T(14 MHz)下被转换为K-39的频率。使用多回波序列和反转恢复序列估计健康大腿、肌肉和脑组织的松弛时间。采用非线性最小二乘曲线拟合工具进行数据分析。对健康人体大腿肌肉和大脑进行了活体K-39磁共振成像。结果：使用定制的频率转换方案，使用商用的7-T磁共振成像系统，K-39磁共振成像是可行的。人体大腿肌肉和大脑的标称空间分辨率分别为8 x 8 x 16 mm(3)和9.5 x 9.5 x 9.5 mm(3)。肌肉和脑组织的获取时间均为30分钟。测量的大腿肌肉组织的钾浓度(未校正脂肪含量)在预期范围内。结论：人体体内K-39磁共振成像可以在临床可行的测量时间内(约30分钟)进行，体素大小约为1毫升。(C)RSNA，2013年
Purpose: To implement potassium 39 (K-39) magnetic resonance (MR) imaging with a 7-T MR imaging system and to evaluate its feasibility for in vivo imaging of human muscle and brain.Materials and Methods: Three healthy volunteers were examined with approval of the ethical review board of Heidelberg University. Written informed consent was obtained from all volunteers. Because the available 7-T MR imaging system did not support K-39, a frequency conversion scheme was developed and connected to the imaging unit. The standard X-nucleus frequency of lithium 7 (115 MHz) was converted to the frequency of K-39 at 7 T (14 MHz). Relaxation times of healthy thigh muscle and brain tissue were estimated by using multiple-echo and inversion-recovery sequences. Data analysis was conducted with a nonlinear least squares curve fitting tool. In vivo K-39 MR imaging of healthy human thigh muscle and brain was performed.Results: With use of the custom-built frequency conversion scheme, K-39 MR imaging is feasible with a commercially available 7-T MR imaging system. Nominal spatial resolutions of 8 x 8 x 16 mm(3) and 9.5 x 9.5 x 9.5 mm(3) were achieved for human thigh muscle and brain, respectively. Acquisition time was 30 minutes for both muscle and brain tissue. The measured potassium concentration (uncorrected for fat fraction) of thigh muscle tissue (112-124 mmol/L) lies within the expected range.Conclusion: In vivo K-39 MR imaging in humans can be performed in clinically feasible measurement times (approximately 30 minutes) with voxel sizes of approximately 1 mL. (C)RSNA, 2013