Mechanisms and Dynamics of Protein Acetylation in Mitochondria.
Mechanisms and Dynamics of Protein Acetylation in Mitochondria.
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DOI：
10.1016/j.tibs.2015.12.006
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发表时间：
2016-03
影响因子：
13.8
通讯作者：
Denu JM
中科院分区：
文献类型：
--
作者：
Baeza J;Smallegan MJ;Denu JM
可逆的蛋白质乙酰化是控制蛋白质功能的主要调节机制。通过遗传操作，饮食扰动和新的蛋白质组学技术，蛋白质乙酰化的各种功能正在成为焦点。线粒体中的蛋白质乙酰化已经成为研究的中心，63%的线粒体定位蛋白质含有赖氨酸乙酰化位点。在这里，我们总结了该领域，并讨论了突出的主题，包括虚假与有针对性的乙酰化，SIRT3脱乙酰化，非酶乙酰化的作用，以及显示高和低化学计量的调节乙酰化的分子模型。
Reversible protein acetylation is a major regulatory mechanism for controlling protein function. Through genetic manipulations, dietary perturbations, and new proteomic technologies, the diverse functions of protein acetylation are coming into focus. Protein acetylation in mitochondria has taken center stage, revealing that 63% of mitochondrially localized proteins contain lysine acetylation sites. Here we summarize the field, and discuss salient topics that cover spurious versus targeted acetylation, the role of SIRT3 deacetylation, nonenzymatic acetylation, and molecular models for regulatory acetylations that display high and low stoichiometry.