A novel study design to investigate the early-life origins of asthma in children (SAGE study)
A novel study design to investigate the early-life origins of asthma in children (SAGE study)
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DOI：
10.1111/j.1398-9995.2009.02033.x
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发表时间：
2009-08-01
期刊：
影响因子：
12.4
通讯作者：
Becker, A. B.
中科院分区：
文献类型：
--
作者：
Kozyrskyj, A. L.;HayGlass, K. T.;Becker, A. B.
这是对哮喘、基因与环境研究（SAGE）的描述，这是一个从省级医疗管理记录中创建的新型出生队列。它是一个基于普通人群的队列，由加拿大马尼托巴省城市和农村环境中哮喘高风险和低风险的儿童组成。SAGE研究获取了1995年出生儿童的完整纵向医疗记录，并包含与哮喘发展相关的早期生活暴露的详细信息，例如抗生素使用和免疫接种情况。在这个出生队列中嵌套了一个病例对照研究，该研究旨在通过详细调查和家庭灰尘采样收集家庭环境暴露信息，确认儿童的哮喘状况，并利用这些数据验证医疗数据库中哮喘的测量指标，确定哮喘患者免疫系统对先天性和适应性免疫刺激反应的差异，对儿童可能与哮喘发展相关的基因进行基因分型，并研究预先确定的保护性与过敏性免疫反应的表观遗传调控。SAGE研究是来自儿科过敏、人群健康、免疫学以及遗传和环境流行病学研究人员的多学科合作项目。因此，它为研究生、博士后和临床医生提供了一个富有成果的跨学科培训平台。
This is a description of the Study of Asthma, Genes and the Environment (SAGE), a novel birth cohort created from provincial healthcare administrative records. It is a general population-based cohort, composed of children at high and low risk for asthma, living in urban and rural environments in Manitoba, Canada. The SAGE study captures the complete longitudinal healthcare records of children born in 1995 and contains detailed information on early-life exposures, such as antibiotic utilization and immunization, in relationship to the development of asthma. Nested within the birth cohort is a case-control study, which was created to collect information on home environmental exposures from detailed surveys and home dust sampling, to confirm asthma status in children and use this data to validate healthcare database measures of asthma, to determine differences in immune system responsiveness to innate and adaptive immune stimuli in asthma, to genotype children for genes likely associated with the development of asthma and to study the epigenetic regulation of preestablished protective vs allergic immune responses. The SAGE study is a multidisciplinary collaboration of researchers from pediatric allergy, population health, immunology, and genetic and environmental epidemiology. As such, it serves as a fertile, interdisciplinary training ground for graduate students, and postdoctoral and clinician fellows.