Relationships between brachial-ankle pulse wave velocity and conventional atherosclerotic risk factors in community-dwelling people
Relationships between brachial-ankle pulse wave velocity and conventional atherosclerotic risk factors in community-dwelling people
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DOI：
10.1016/j.ypmed.2004.04.026
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发表时间：
2004-12-01
影响因子：
5.1
通讯作者：
Shinkai, S
中科院分区：
文献类型：
--
作者：
Fujiwara, Y;Chaves, P;Shinkai, S
背景研制了一种简单的臂踝脉搏波传导速度（baPWV）测量仪。本研究的目的是使用该仪器研究baPWV与传统动脉粥样硬化危险因素之间的关系。方法。2002年6月，居住在农村地区的632名日本人（234名男性和398名女性）参加了一项市政医疗健康调查，其中包括baPWV测量和传统的临床检查。男性的baPWV明显高于女性。未发现性别和年龄对baPWV的相互作用。多元线性回归分析显示年龄、血流动力学因素（舒张压、脉压和心率）、血红蛋白A1c、当前饮酒和吸烟状态以及轻度视网膜病变对较高的baPWV具有显著的独立影响。在这个农村人群中，年龄、性别和血流动力学因素与baPWV独立相关，沿着传统的动脉粥样硬化危险因素，尽管baPWV与动脉粥样硬化性疾病或亚临床动脉粥样硬化病史之间无显著相关性，但轻度视网膜改变除外。(C)2004年癌症预防研究所和爱思唯尔公司。All rights reserved.
Background. A simple instrument has been developed to measure brachial-ankle pulse wave velocity (baPWV). The aim of the present study was to use this instrument to study the relationship between baPWV and conventional atherosclerotic risk factors.Methods. Community-dwelling Japanese (632) living in a rural area (234 men and 398 women) participated in a municipal medical health survey that included baPWV measurement and a traditional clinical examination, conducted in June, 2002.Results. Men had a significantly higher baPWV than women. No interaction between gender and age on baPWV was identified. Multiple linear regression analysis indicated that age, hemodynamic factors (diastolic blood pressure, pulse pressure, and heart rate), hemoglobinA1c, current drinking and smoking status, and mild retinal changes had significant independent influences on higher baPWV.Conclusions. In this rural population, age, gender, and hemodynamic factors were independently associated with baPWV, along with traditional atherosclerotic risk factors, although no significant associations between baPWV and histories of atherosclerotic diseases or subclinical atherosclerosis except for mild retinal changes were demonstrated. (C) 2004 The Institute For Cancer Prevention and Elsevier Inc. All rights reserved.