Differences in the distribution and nature of the interstitial telomeric (TTAGGG)n sequences in the chromosomes of the Giraffidae, okapai (Okapia johnstoni), and giraffe (Giraffa camelopardalis): evidence for ancestral telomeres at the okapi polymorphic rob(5;26) fusion site.
Differences in the distribution and nature of the interstitial telomeric (TTAGGG)n sequences in the chromosomes of the Giraffidae, okapai (Okapia johnstoni), and giraffe (Giraffa camelopardalis): evidence for ancestral telomeres at the okapi polymorphic rob(5;26) fusion site.
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长颈鹿科、霍加狓 (Okapia johnstoni) 和长颈鹿 (Giraffacamelopardalis) 染色体间质端粒 (TTAGGG)n 序列的分布和性质的差异：霍加狓多态性 rob(5;26) 融合中祖先端粒的证据
DOI：
10.1159/000134211
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发表时间：
1996
期刊：
影响因子：
--
通讯作者：
Paul Petit
中科院分区：
文献类型：
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作者：
J. Vermeesch;W. Meurichy;H. V. D. Berghe;P. Marynen;Paul Petit
染色体内端粒序列（TTAGGG）n进行了分析，在两个成员的家庭长颈鹿，长颈鹿和霍加皮。长颈鹿的二倍体染色体数目为2n = 30，而霍加皮的染色体数目从2n = 46到2n = 45和2n = 44不等，这是由于最近的罗伯逊融合事件。我们在这些物种中检测到的间质端粒有两种类型：（1）在霍加皮中，长的间质端粒元件存在于罗布的融合位点（4;26）。这种间质端粒元件的性质表明，它是参与融合事件的祖先染色体端粒的残余物。(2)在长颈鹿中，作为卫星DNA的一部分的短延伸或简并端粒序列存在于染色体内位点。本研究的结果提供了深入了解的起源间质端粒序列的长颈鹿科。
Intrachromosomal telomeric sequences (TTAGGG)n were analyzed in the two members of the family Giraffidae, the giraffe and the okapi. The giraffe has a diploid chromosome number of 2n = 30, whereas the okapi chromosome number varies from 2n = 46 to 2n = 45 and 2n = 44 due to a "recent" Robertsonian fusion event. The interstitial telomeres that we detected in these species are of two types: (1) In the okapi, a long interstitial telomeric element is present at the fusion site of the rob(4;26). The nature of this interstitial telomeric element suggests that it is a remnant of the telomeres of the ancestral chromosomes that participated in the fusion event. (2) In the giraffe, short stretches or degenerate telomeric sequences which are part of the satellite DNA are present at intrachromosomal sites. The results of this study provide insights into the origin of interstitial telomeric sequences in the Giraffidae.