Domino Reaction to Functionalized 2-Hydroxybenzophenones from Electron-Deficient Chromones and 1,3-Dicarbonyl Compounds
Domino Reaction to Functionalized 2-Hydroxybenzophenones from Electron-Deficient Chromones and 1,3-Dicarbonyl Compounds
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缺电子色酮和 1,3-二羰基化合物对官能化 2-羟基二苯甲酮的多米诺反应
DOI：
10.1021/jo201384f
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发表时间：
2011-10-21
影响因子：
3.6
通讯作者：
Hu, Youhong
中科院分区：
文献类型：
--
作者：
Chen, Hong;Xie, Fuchun;Hu, Youhong
在温和的条件下，通过碱促进的一锅串联反应，将缺电子色酮稠合二烯1和1，3-二羰基化合物2转化为功能化的2-羟基二苯甲酮3。这种多米诺骨牌过程，它涉及多个反应，包括迈克尔加成/环化/消除，作为一种有效的，经济的，生态友好的方法，用于建设多样化的2-羟基二苯甲酮支架没有过渡金属催化剂和惰性气氛。
A base-promoted one-pot tandem reaction sequence has been developed to transform electron-deficient chromone-fused dienes 1 and 1,3-dicarbonyl compounds 2 to functionalized 2-hydroxybenzophenones 3 under mild conditions. This domino process, which involves multiple reactions, including Michael addition/cyclization/elimination, serves as an efficient, economic, and eco-friendly method for the construction of diversified 2-hydroxybenzophenone scaffolds without a transition-metal catalyst and inert atmosphere.