Metabolic plasticity and hematopoietic stem cell biology.
Metabolic plasticity and hematopoietic stem cell biology.
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DOI：
10.1097/moh.0b013e328360ab4d
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发表时间：
2013-07
影响因子：
3.2
通讯作者：
Qu CK
中科院分区：
文献类型：
--
作者：
Hsu P;Qu CK
存在于缺氧环境中的造血干细胞（HSC）既可以自我更新，也可以产生后代。已经确定了这些细胞过程的多种调节机制。新的证据表明，新陈代谢和生物能量学与其他调控网络在决定干细胞命运方面发挥着重要作用。在这篇评论中，我们将讨论该领域的最新进展。最近的研究帮助定义和重新定义了 HSC 的代谢调节。静息的静止干细胞主要利用无氧糖酵解来产生能量，并且这种代谢程序是维持功能性静止状态所必需的。然而，当它们退出这种状态并快速增殖并分化成不同的血细胞类型时，能量代谢的强劲上调有望满足快速增长的能量需求。造血干细胞代谢失调会导致各种血液疾病，包括白血病。能量代谢和 HSC 活动以高度复杂和精心策划的方式相互影响和相互联系。了解 HSC 功能的代谢调节对于基于 HSC 的治疗和白血病发生研究具有重要意义。
Hematopoietic stem cells (HSCs) residing in the hypoxic niches can both self-renew and give rise to progeny. Multiple regulatory mechanisms for these cellular processes have been identified. Emerging evidence has revealed that metabolism and bioenergetics play important roles in determining stem cell fate in concert with other regulatory networks. In this review, we will discuss recent advances in this field. Recent studies have helped define and redefine metabolic regulation of HSCs. Resting quiescent stem cells use primarily anaerobic glycolysis for energy production and this metabolic program is required to maintain a functional quiescent state. However, when they exit this state and rapidly proliferate and differentiate into different blood cell types, a robust upregulation of energy metabolism is expected to meet the quickly rising energy demand. Dysregulation of metabolism in HSCs results in various blood disorders, including leukemia. Energy metabolism and HSC activity influence and interlink each other in a highly sophisticated and orchestrated manner. Understanding metabolic regulation of HSC function has significant implications for HSC-based therapies and leukemogenesis research.