Generating hepatic cell lineages from pluripotent stem cells for drug toxicity screening.
Generating hepatic cell lineages from pluripotent stem cells for drug toxicity screening.
复制标题
DOI：
10.1016/j.scr.2010.02.002
复制
发表时间：
2010-07
影响因子：
1.2
通讯作者：
Hanley, Neil A.
中科院分区：
文献类型：
--
作者：
Baxter, Melissa A.;Rowe, Cliff;Alder, Jane;Harrison, Sean;Hanley, Karen Piper;Park, B. Kevin;Kitteringham, Neil R.;Goldring, Chris E.;Hanley, Neil A.
肝毒性是制药行业面临的一个巨大且日益严重的问题。在药物发现过程中早期发现问题有利于最大限度地降低成本并提高患者安全性。然而，目前的蜂窝模型是次优的。本文综述了多能干细胞在肝细胞谱系产生中的潜在应用。它首先强调了制药行业面临的问题的规模，药物诱导的肝损伤的确切性质，以及在药物发现途径中需要额外的细胞模型。目前的研究进行了讨论，主要是产生肝细胞样细胞，而不是其他肝细胞类型。此外，努力确定一些主要的障碍仍然在翻译什么是目前的假设驱动的实验室研究到有意义的平台技术的制药行业。
Hepatotoxicity is an enormous and increasing problem for the pharmaceutical industry. Early detection of problems during the drug discovery pathway is advantageous to minimize costs and improve patient safety. However, current cellular models are sub-optimal. This review addresses the potential use of pluripotent stem cells in the generation of hepatic cell lineages. It begins by highlighting the scale of the problem faced by the pharmaceutical industry, the precise nature of drug-induced liver injury and where in the drug discovery pathway the need for additional cell models arises. Current research is discussed, mainly for generating hepatocyte-like cells rather than other liver cell-types. In addition, an effort is made to identify where some of the major barriers remain in translating what is currently hypothesis-driven laboratory research into meaningful platform technologies for the pharmaceutical industry.
登录
查看更多内容
影响因子：
11.8
作者：
Chung, Won-Suk;Shin, Chong Hyun;Stainier, Didier Y. R.
通讯作者：
Stainier, Didier Y. R.
影响因子：
4.8
作者：
Cho, Cheul H.;Parashurama, Natesh;Yarmush, Martin L.
通讯作者：
Yarmush, Martin L.
影响因子：
5.2
作者：
Chiao, Eric;Elazar, Menashe;Baker, Julie
通讯作者：
Baker, Julie
影响因子：
64.8
作者：
Chambers, Ian;Silva, Jose;Smith, Austin
通讯作者：
Smith, Austin
影响因子：
5.2
作者：
Agarwal, Sadhana;Holton, Katherine L.;Lanza, Robert
通讯作者：
Lanza, Robert