Prevalence of the metabolic syndrome in American adolescents - Findings from the Third National Health and Nutrition Examination Survey
Prevalence of the metabolic syndrome in American adolescents - Findings from the Third National Health and Nutrition Examination Survey
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DOI：
10.1161/01.cir.0000145117.40114.c7
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发表时间：
2004-10-19
期刊：
影响因子：
37.8
通讯作者：
Rifai, N
中科院分区：
文献类型：
--
作者：
de Ferranti, SD;Gauvreau, K;Rifai, N
代谢综合征（MetS）的定义是由成人治疗小组第三次报告（ATP III）使用的标准容易应用于临床医生和研究人员。方法和结果-我们使用类似于ATP III的标准将儿科MetS定义为大于或等于以下3项：（1）空腹甘油三酯大于或等于1.1 mmol/L（100 mg/dL）;（2）性别、年龄和身高的HDL第90百分位数。美国青少年代谢综合征的患病率估计与第三次全国健康和营养调查1988年至1994年。在1960名年龄大于或等于12岁且禁食大于或等于8小时的儿童中，三分之二至少有一种代谢异常，近十分之一有代谢综合征。人种/种族分布与成人相似：墨西哥裔美国人，其次是非西班牙裔白人，MetS的患病率高于非西班牙裔黑人（分别为12.9%，[95% CI 10.4%至15.4%]; 10.9%，[95% CI 8.4%至13.4%];和2.5%，[95% CI 1.3%至3.7%]）。近三分之一（31.2% [95%CI 28.3%至34.1%]）的超重/肥胖的青少年有MetS.Conclusions-Our定义的儿科代谢综合征，旨在密切类似于ATP III，发现代谢综合征是常见的青少年，并有类似的种族/民族分布的成年人在这个代表性的国家样本。由于儿童期代谢综合征可能会持续到成年期，因此早期识别可能有助于针对性干预，以改善未来的心血管健康。
Background-Metabolic syndrome (MetS) is defined by the Third Report of the Adult Treatment Panel (ATP III) using criteria easily applied by clinicians and researchers. There is no standard pediatric definition.Methods and Results-We defined pediatric MetS using criteria analogous to ATP III as greater than or equal to3 of the following: (1) fasting triglycerides greater than or equal to1.1 mmol/L (100 mg/dL); (2) HDL 90th percentile for gender, age, and height. MetS prevalence in US adolescents was estimated with the Third National Health and Nutritional Survey 1988 to 1994. Among 1960 children aged greater than or equal to12 years who fasted greater than or equal to8 hours, two thirds had at least 1 metabolic abnormality, and nearly 1 in 10 had MetS. The racial/ethnic distribution was similar to adults: Mexican-Americans, followed by non-Hispanic whites, had a greater prevalence of MetS compared with non-Hispanic blacks (12.9%, [95% CI 10.4% to 15.4%]; 10.9%, [95% CI 8.4% to 13.4%]; and 2.5%, [95% CI 1.3% to 3.7%], respectively). Nearly one third (31.2% [95% CI 28.3% to 34.1%]) of overweight/obese adolescents had MetS.Conclusions-Our definition of pediatric MetS, designed to be closely analogous to ATP III, found MetS is common in adolescents and has a similar racial/ethnic distribution to adults in this representative national sample. Because childhood MetS likely tracks into adulthood, early identification may help target interventions to improve future cardiovascular health.