Emergence of penicillin-nonsusceptible Streptococcus pneumoniae clones expressing serotypes not present in the antipneumococcal conjugate vaccine
Emergence of penicillin-nonsusceptible Streptococcus pneumoniae clones expressing serotypes not present in the antipneumococcal conjugate vaccine
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DOI：
10.1086/425908
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发表时间：
2004-12-15
影响因子：
6.4
通讯作者：
Dagan, R
中科院分区：
文献类型：
--
作者：
Porat, N;Arguedas, A;Dagan, R
背景对青霉素不敏感的肺炎链球菌分离株主要局限于少数血清型。被膜转化可能是传播新血清型抗生素耐药性的机制。方法。对1998 - 2003年从以色列儿童中分离的46株11 A型鼻咽和中耳液（MEF）、45株15 B/C型MEF进行了抗生素谱和分子分型
Background. Penicillin-nonsusceptible Streptococcus pneumoniae isolates are confined mainly to a few serogroups. Capsular transformation may serve as a mechanism for spreading antibiotic resistance to new serotypes.Methods. Antibiogram and molecular typing, by pulsed-field gel electrophoresis (PFGE), were performed on 46 nasopharyngeal and middle ear fluid (MEF) isolates expressing serotype 11A, 45 MEF isolates expressing serotype 15B/C ( recovered during 1998 - 2003 from Israeli children