Arginase-1-expressing macrophages are dispensable for resistance to infection with the gastrointestinal helminth Trichuris muris.
Arginase-1-expressing macrophages are dispensable for resistance to infection with the gastrointestinal helminth Trichuris muris.
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DOI：
10.1111/j.1365-3024.2011.01300.x
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发表时间：
2011-07
影响因子：
2.2
通讯作者：
Cruickshank SM
中科院分区：
文献类型：
--
作者：
Bowcutt R;Bell LV;Little M;Wilson J;Booth C;Murray PJ;Else KJ;Cruickshank SM
选择性激活的巨噬细胞（AAM）在对多种胃肠道蠕虫（如Heligmosomoides bakeri和Nippostrongylus brasiliensis）的免疫应答中具有关键作用。此外，AAM还参与了曼氏血吸虫感染中感染诱导的病理学的解决。AAM部分地通过酶精氨酸酶-1（Arg 1）发挥其活性，所述酶精氨酸酶-1（Arg 1）将L-精氨酸水解成尿素和鸟氨酸，并且可以提供用于脯氨酸和多胺产生的前体底物。鼠鞭虫是一种寄生在大肠中的蠕虫，其抗性的特征在于Th 2 T细胞应答，其在感染的局部环境中驱动交替活化的巨噬细胞产生。探讨AAMs在T.感染，我们使用了独立的遗传和药理学模型的β-淀粉酶缺乏症。在急性感染和Th 2主导的免疫中，脱氢酶缺陷模型正常排出蠕虫。巨噬细胞Arg 1缺陷小鼠在急性和慢性感染中表现出与野生型动物相当的细胞因子和抗体水平。我们还发现AAMs和Arg 1在T.慢性（Th 1为主）或急性（Th 2为主）感染。我们的数据表明，与其他胃肠道蠕虫不同，Arg 1在AAM中的表达对于T.小鼠在蠕虫引起的炎症的有效解决。
Alternatively activated macrophages (AAMs) have key roles in the immune response to a variety of gastrointestinal helminths such as Heligmosomoides bakeri and Nippostrongylus brasiliensis. In addition, AAMs have been implicated in the resolution of infection-induced pathology in Schistosoma mansoni infection. AAMs exert their activity in part via the enzyme arginase-1 (Arg1), which hydrolyses l-arginine into urea and ornithine, and can supply precursor substrate for proline and polyamine production. Trichuris muris is a worm that resides in the large intestine with resistance being characterized by a Th2 T-cell response, which drives alternatively activated macrophage production in the local environment of the infection. To investigate the role of AAMs in T. muris infection, we used independent genetic and pharmacologic models of arginase deficiency. In acute infection and Th2-dominated immunity, arginase-deficient models expelled worms normally. Macrophage-Arg1-deficient mice showed cytokine and antibody levels comparable to wild-type animals in acute and chronic infection. We also found no role for AAMs and Arg1 in infection-induced pathology in the response to T. muris in either chronic (Th1 dominated) or acute (Th2 dominated) infections. Our data demonstrate that, unlike other gastrointestinal helminths, Arg1 expression in AAMs is not essential for resistance to T. muris in effective resolution of helminth-induced inflammation.
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影响因子：
4.4
作者：
Lucas, Tina;Waisman, Ari;Eming, Sabine A.
通讯作者：
Eming, Sabine A.
影响因子：
3.8
作者：
Modolell M;Choi BS;Ryan RO;Hancock M;Titus RG;Abebe T;Hailu A;Müller I;Rogers ME;Bangham CR;Munder M;Kropf P
通讯作者：
Kropf P
DOI：
10.4049/jimmunol.0902009
发表时间：
2010-06-01
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Herbert DR;Orekov T;Roloson A;Ilies M;Perkins C;O'Brien W;Cederbaum S;Christianson DW;Zimmermann N;Rothenberg ME;Finkelman FD
通讯作者：
Finkelman FD
影响因子：
2.7
作者：
Kisanuki, YY;Hammer, RE;Yanagisawa, M
通讯作者：
Yanagisawa, M
影响因子：
4.4
作者：
Little, MC;Bell, LV;Else, KJ
通讯作者：
Else, KJ