CD8+ T Cell Activation Leads to Constitutive Formation of Liver Tissue-Resident Memory T Cells that Seed a Large and Flexible Niche in the Liver
CD8+ T Cell Activation Leads to Constitutive Formation of Liver Tissue-Resident Memory T Cells that Seed a Large and Flexible Niche in the Liver
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DOI：
10.1016/j.celrep.2018.08.094
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发表时间：
2018-10-02
期刊：
影响因子：
8.8
通讯作者：
Heath, William R.
中科院分区：
文献类型：
--
作者：
Holz, Lauren E.;Prier, Julia E.;Heath, William R.
肝组织驻留记忆T （Trm）细胞在整个鼻窦炎中迁移，能够抵御疟疾孢子虫的攻击。为了了解肝脏Trm细胞的发育，我们检查了它们形成的各种条件。虽然在幼稚小鼠中发现了肝脏Trm细胞，但它们的存在是由抗原特异性和所需的IL-15决定的。肝脏Trm细胞也在体外激活而非初始CD8(+) T细胞过继转移后形成，这表明激活是必要的，但肝脏内的抗原呈递不是强制性的。这些Trm细胞以36天的半衰期在肝窦中徘徊，占据了一个大的生态位，可以依次添加，而不会对后续的Trm细胞群产生影响。总之，我们的研究结果表明，肝脏Trm细胞的形成是CD8(+) T细胞激活的正常结果，但炎症和抗原信号优先调整其发展。
Liver tissue-resident memory T (Trm) cells migrate throughout the sinusoids and are capable of protecting against malaria sporozoite challenge. To gain an understanding of liver Trm cell development, we examined various conditions for their formation. Although liver Trm cells were found in naive mice, their presence was dictated by antigen specificity and required IL-15. Liver Trm cells also formed after adoptive transfer of in vitro-activated but not naive CD8(+) T cells, indicating that activation was essential but that antigen presentation within the liver was not obligatory. These Trm cells patrolled the liver sinusoids with a half-life of 36 days and occupied a large niche that could be added to sequentially without effect on subsequent Trm cell cohorts. Together, our findings indicate that liver Trm cells form as a normal consequence of CD8(+) T cell activation during essentially any infection but that inflammatory and antigenic signals preferentially tailor their development.