Towards Ideal Synthesis: Alkenylation of Aryl C-H Bonds by a Fujiwara-Moritani Reaction
Towards Ideal Synthesis: Alkenylation of Aryl C-H Bonds by a Fujiwara-Moritani Reaction
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DOI：
10.1002/chem.201303670
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发表时间：
2014-01-13
影响因子：
4.3
通讯作者：
Lu, Wenjun
中科院分区：
文献类型：
--
作者：
Zhou, Lihong;Lu, Wenjun
概述了钯催化芳烃与烯烃氧化偶联生成烯基芳烃的藤原-森谷反应的最新进展。强调在Pd、Rh或Ru催化剂的存在下，在芳香环上的各种螯合基团的帮助下，芳基邻位或间位碳氢活化的区域选择性可以很好地控制。本文还讨论了从简单芳烃，特别是从缺电子芳烃中催化芳基C-H键的烯化反应。这些先进的协议不仅使藤原-森谷反应在有机合成中更加有用和适用，而且为进一步发展正常C-H键的功能化指明了道路。
An overview of recent progress in the Fujiwara-Moritani reaction, which is the palladium-catalyzed oxidative coupling of arenes with olefins to afford alkenyl arenes, is described. It is emphasized that regioselectivity on aryl ortho- or meta-C-H activation could be controlled very well in the presence of Pd, Rh, or Ru catalysts with the assistance of various chelation groups on aromatic rings in this coupling reaction. Catalytic alkenylation of aryl C-H bonds from simple arenes is also discussed, especially from electron-deficient arenes. These advanced protocols would not only make the Fujiwara-Moritani reaction more useful and applicable in organic synthesis but also light the way for the further development of the functionalization of normal C-H bonds.