Post-transcriptional Regulation of Immunological Responses through Riboclustering.
Post-transcriptional Regulation of Immunological Responses through Riboclustering.
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DOI：
10.3389/fimmu.2016.00161
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发表时间：
2016
影响因子：
7.3
通讯作者：
Khan N
中科院分区：
文献类型：
--
作者：
Ganguly K;Giddaluru J;August A;Khan N
免疫细胞的免疫编程会根据不断变化的环境信号而变化。这一过程由调节编码各种免疫介质（包括细胞因子和趋化因子）的 mRNA 翻译命运的修饰剂促进，而这些调节剂又决定了免疫系统的快速激活、耐受性和可塑性。由 mRNA 转录物中的特定序列元件募集的 RNA 结合蛋白 (RBP) 就是这样的修饰剂之一。这些 RBP 形成 RBP-RNA 复合物，称为“核簇”。这些核糖簇充当 RNA 分选机器，根据核糖簇的组成，控制 mRNA 的翻译、降解或储存。最近的研究结果表明，mRNA 稳态的调节对于控制免疫反应至关重要。在这里，我们介绍了核簇介导的免疫介质转录后调节的最新知识，并重点介绍了它们对急性或慢性炎症性疾病发病机制的影响的最新发现。
Immunological programing of immune cells varies in response to changing environmental signals. This process is facilitated by modifiers that regulate the translational fate of mRNAs encoding various immune mediators, including cytokines and chemokines, which in turn determine the rapid activation, tolerance, and plasticity of the immune system. RNA-binding proteins (RBPs) recruited by the specific sequence elements in mRNA transcripts are one such modifiers. These RBPs form RBP–RNA complexes known as “riboclusters.” These riboclusters serve as RNA sorting machinery, where depending upon the composition of the ribocluster, translation, degradation, or storage of mRNA is controlled. Recent findings suggest that this regulation of mRNA homeostasis is critical for controlling the immune response. Here, we present the current knowledge of the ribocluster-mediated post-transcriptional regulation of immune mediators and highlight recent findings regarding their implications for the pathogenesis of acute or chronic inflammatory diseases.