Exposure to Perfluoroalkyl Substances in a Cohort of Women Firefighters and Office Workers in San Francisco.
Exposure to Perfluoroalkyl Substances in a Cohort of Women Firefighters and Office Workers in San Francisco.
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DOI：
10.1101/19005652
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发表时间：
2019-09
影响因子：
11.4
通讯作者：
Jessica Trowbridge;R. Gerona;Thomas Lin;R. Rudel;Vincent Bessonneau;Heather Buren;R. Morello-Frosch
中科院分区：
文献类型：
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作者：
Jessica Trowbridge;R. Gerona;Thomas Lin;R. Rudel;Vincent Bessonneau;Heather Buren;R. Morello-Frosch
对消防员的研究表明，与普通人群相比，他们接触致癌化合物的机会增加，某些癌症的发病率也升高，但这项研究几乎完全集中在男性身上。为了解决这一差距，女性消防员生物监测合作组织创建了一个生物样本档案，并分析了旧金山弗朗西斯科女性消防员（N = 86）和办公室工作人员（N = 84）的全氟烷基物质（PFAS）水平。采集血清样本，采用液相色谱-串联质谱法（LC-MS/MS）进行分析，以测量和比较消防员和办公室工作人员之间的PFAS水平。在至少70%的研究人群中检测到12种PFAS同系物中的7种，在100%的参与者中检测到4种同系物。在按职业比较PFAS水平并调整潜在混杂因素的回归模型中，消防员的PFAS几何平均浓度高于办公室工作人员PFHxS（2.22（95% CI = 1.55，3.18））、PFUnDA（1.83（95% CI = 0.97，3.45））和PFNA（1.26（95% CI = 1.01，1.58））。在消防员中，职业位置预测的安全消防员和官员有较高的PFNA，PFOA，PFDA和PFUNDA水平相比，司机。与办公室工作人员相比，女性消防员暴露于更高水平的某些PFAS，这表明其中一些暴露可能与职业有关。
Studies of firefighters have shown increased exposures to carcinogenic compounds and elevated rates of certain cancers compared to the general population, yet this research has focused almost exclusively on men. To address this gap, the Women Firefighters Biomonitoring Collaborative created a biological sample archive and analyzed levels of perfluoroalkyl substances (PFAS) among women firefighters (N = 86) and office workers (N = 84) in San Francisco. Serum samples were collected and analyzed using liquid chromatography-tandem mass spectrometry (LC-MS/MS) to measure and compare PFAS levels between firefighters and office workers. 7 of 12 PFAS congeners were detected in the least 70% of the study population, and 4 congeners were detected in 100% of participants. In regression models comparing PFAS levels by occupation and adjusting for potential confounders, firefighters had higher geometric mean concentrations of PFAS compared to office workers PFHxS (2.22 (95% CI = 1.55, 3.18)), PFUnDA (1.83 (95% CI = 0.97, 3.45)), and PFNA (1.26 (95% CI = 1.01, 1.58)). Among firefighters, occupational position predicted exposure-firefighters and officers had higher PFNA, PFOA, PFDA, and PFUnDA levels compared to drivers. Women firefighters are exposed to higher levels of some PFAS compared to office workers, suggesting that some of these exposures may be occupationally related.