Quaternized Chitosan-Capped Mesoporous Silica Nanoparticles as Nanocarriers for Controlled Pesticide Release.
Quaternized Chitosan-Capped Mesoporous Silica Nanoparticles as Nanocarriers for Controlled Pesticide Release.
复制标题
季铵化壳聚糖封端介孔二氧化硅纳米粒子作为纳米载体用于控制农药释放
DOI：
10.3390/nano6070126
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发表时间：
2016-06-28
期刊：
影响因子：
--
通讯作者：
Huang Q
中科院分区：
文献类型：
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作者：
Cao L;Zhang H;Cao C;Zhang J;Li F;Huang Q
基于纳米技术的农药配方将确保有效利用农业投入。采用液晶模板法制备了粒径为~110 nm、孔径为~3.7 nm的介孔二氧化硅纳米颗粒（MSNs）。制备了一种水溶性壳聚糖（CS）衍生物（N-（2-羟基）丙基-3-三甲基氯化铵（HTCC）），并将其包覆在pyraclostrobin负载的msn表面。物理化学和结构分析表明，静电相互作用和氢键作用是形成htcc包覆msn的主要作用力。HTCC涂层比裸msn作为单一包封剂（26.7%）大大提高了负载效率（LC）（40.3%）。利用扫描电镜（SEM）和透射电镜（TEM）研究了纳米颗粒的微观结构。负载吡唑啉酯的纳米颗粒表现出初始爆裂和随后的缓释行为。在初始阶段，htcc封顶的微信比裸微信发布速度更快。半剂量吡唑菌酯技术负载htcc包封的msn对天冬酰胺（Phomopsis asparagi, Sacc.）的杀真菌活性几乎相同，明显减少了施用量，提高了利用效率。因此，htcc修饰的msn作为纳米载体在农化领域具有巨大的应用潜力。
Nanotechnology-based pesticide formulations would ensure effective utilization of agricultural inputs. In the present work, mesoporous silica nanoparticles (MSNs) with particle diameters of ~110 nm and pore sizes of ~3.7 nm were synthesized via a liquid crystal templating mechanism. A water-soluble chitosan (CS) derivative (N-(2-hydroxyl)propyl-3-trimethyl ammonium CS chloride, HTCC) was successfully capped on the surface of pyraclostrobin-loaded MSNs. The physicochemical and structural analyses showed that the electrostatic interactions and hydrogen bonding were the major forces responsible for the formation of HTCC-capped MSNs. HTCC coating greatly improved the loading efficiency (LC) (to 40.3%) compared to using bare MSNs as a single encapsulant (26.7%). The microstructure of the nanoparticles was revealed by scanning electron microscopy (SEM) and transmission electron microscopy (TEM). The pyraclostrobin-loaded nanoparticles showed an initial burst and subsequent sustained release behavior. HTCC-capped MSNs released faster than bare MSNs in the initial stage. Pyraclostrobin-loaded HTCC-capped MSNs with half doses of pyraclostrobin technical demonstrated almost the same fungicidal activity against Phomopsis asparagi (Sacc.), which obviously reduced the applied pesticide and enhanced the utilization efficiency. Therefore, HTCC-decorated MSNs demonstrated great potential as nanocarriers in agrochemical applications.