Prostate Cancer Detection With 3 T MRI: Comparison of Diffusion-Weighted Imaging and Dynamic Contrast-Enhanced MRI in Combination With T2-Weighted Imaging
Prostate Cancer Detection With 3 T MRI: Comparison of Diffusion-Weighted Imaging and Dynamic Contrast-Enhanced MRI in Combination With T2-Weighted Imaging
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DOI：
10.1002/jmri.22075
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发表时间：
2010-03-01
影响因子：
4.4
通讯作者：
Sugimura, Kazuro
中科院分区：
文献类型：
--
作者：
Kitajima, Kazuhiro;Kaji, Yasushi;Sugimura, Kazuro
目的：评价弥散加权成像（DWI）和动态对比增强成像（DCEI）联合t2加权成像（T2WI）对相控阵体线圈3t磁共振成像（MRI）检测前列腺癌的诊断能力。材料与方法：对53例血清前列腺特异性抗原（PSA）升高的患者进行T2WI、DWI和DCEI穿刺活检。对单独T2WI（方案A）、T2WI和DWI联合（方案B）、T2WI和DCEI联合（方案Q）、T2WI加DWI和DCEI联合（方案D）获得的数据进行受试者工作特征（ROC）曲线分析。结果：区域分析的灵敏度、特异度、准确度和ROC曲线下面积（Az）分别为61%、91%。方案A中分别为84%和0.8415；方案B分别为76%、94%、90%和0.8931；方案C分别为77%、93%、89%和0.8655；81%, 96%。在方案D中分别为92%和0.8968，ROC分析显示方案A与方案B之间（P = 0.0008）和方案A与方案D之间（P = 0.0004）存在显著差异。结论：在PSA水平升高的患者中，3t MRI联合T2WI、DWI、DCEI可能是诊断前列腺癌的一种合理方法。
Purpose: To evaluate the diagnostic ability of diffusion-weighted imaging (DWI) and dynamic contrast-enhanced imaging (DCEI) in combination with T2-weighted imaging (T2WI) for the detection of prostate cancer using 3 T magnetic resonance imaging (MRI) with a phased-array body coil.Materials and Methods: Fifty-three patients with elevated serum levels of prostate-specific antigen (PSA) were evaluated by T2WI, DWI, and DCEI prior to needle biopsy. The obtained data from T2WI alone (protocol A), a combination of T2WI and DWI (protocol B), a combination T2WI and DCEI (protocol Q, and a combination of T2WI plus DWI and DCEI (protocol D) were subjected to receiver operating characteristic (ROC) curve analysis.Results: The sensitivity, specificity, accuracy, and area under the ROC curve (Az) for region-based analysis were: 61%, 91%. 84%, and 0.8415, respectively, in protocol A; 76%, 94%, 90%, and 0.8931, respectively, in protocol B; 77%, 93%, 89%, and 0.8655, respectively, in protocol C; and 81%, 96%. 92%, and 0.8968, respectively in protocol D. ROC analysis revealed significant differences between protocols A and B (P = 0.0008) and between protocols A and D (P = 0.0004).Conclusion: In patients with elevated PSA levels the combination of T2WI, DWI, DCEI using 3 T MRI may be a reasonable approach for the detection of prostate cancer.