Preparation of Polylactide Microspheres Having Positively or Negatively Charged Surfaces
Preparation of Polylactide Microspheres Having Positively or Negatively Charged Surfaces
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表面带正电或负电的聚丙交酯微球的制备
DOI：
10.1002/mabi.200390001
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发表时间：
2003
期刊：
影响因子：
--
通讯作者：
H. Yamada
中科院分区：
文献类型：
--
作者：
Hidetoshi Arimura;Y. Ohya;T. Ouchi;H. Yamada
描述了具有支化肽端基的聚乳酸（PLA）的合成，所述支化肽端基含有反应性（离子）部分，例如氨基或羧基，并用于制备具有带正电荷或带负电荷表面的PLA基微球（MS）。合成了末端带有羟基和四个氨基或羧基保护基的支链肽（Boc 4 -K3-OH或Bn 4 -E3-OH），并将羟基转化为醇盐，作为L-丙交酯开环聚合的引发位点。随后的脱保护得到分别用具有四个氨基或羧基的支链肽封端的PLA（K3-PLA和E3-PLA）。K3-PLA和E3-PLA经酸或碱处理后分别转化为K4 + 3 -PLA和E4 - 3 -PLA.然后使用K 4+ 3 -PLA或E 4- 3 -PLA作为表面活性剂制备具有带电表面的MS [MS（K 4+ 3 -PLA）或MS（E 4- 3 -PLA）]。通过胶体滴定和Zeta电位分析证实了MS的离子表面状态。
The syntheses of polylactides (PLAs) with branched peptide end groups containing reactive (ionic) moieties such as amino or carboxyl groups are described and were used to prepare PLA-based microspheres (MSs) with positively or negatively charged surfaces. Branched peptides with hydroxyl end groups and four protected amino or carboxyl groups, Boc 4 -K 3 -OH or Bn 4 -E 3 -OH, were synthesized, and the hydroxyl group converted to an alkoxide and was used as the initiation site for the ring-opening polymerization of L-lactide. Subsequent deprotection gave PLAs endcapped with branched peptides having four amino or carboxyl groups, respectively (K 3 -PLA and E 3 -PLA). K 3 -PLA and E 3 -PLA were converted to K 4+ 3 -PLA and E 4- 3 -PLA by acid or base treatment, respectively. MSs with charged surfaces were then prepared using K 4+ 3 -PLA or E 4- 3 -PLA as a surfactant [MS(K 4+ 3 -PLA) or MS(E 4- 3 -PLA)]. The ionic surface state of the MSs was confirmed by colloidal titration and zeta potential analysis.