Dysosmia and dysgeusia associated with duloxetine
Dysosmia and dysgeusia associated with duloxetine
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与度洛西汀相关的嗅觉障碍和味觉障碍
DOI：
10.1136/bcr-2017-222470
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发表时间：
2017
期刊：
影响因子：
0.9
通讯作者：
Sugawara H
中科院分区：
文献类型：
--
作者：
Yoshida K;Fukuchi T;Sugawara H
血清素-去甲肾上腺素再摄取抑制剂的常见不良反应是恶心、口干、头晕和头痛。我们描述了一位患有嗅觉障碍和随后与度洛西汀相关的味觉障碍的患者的病例。一名68岁的日本女性，有1型糖尿病、高血压、失眠和反流性食管炎病史，因双侧腿部疼痛就诊于当地医院；她接受了度洛西汀治疗。然而，4周后，她闻到了臭鸡蛋味，出现恶心、呕吐症状，入院治疗。我们使用 T&T 嗅觉阈值测试诊断嗅觉障碍，使用滤纸盘法诊断味觉障碍。使用味觉测定法评估味道。我们怀疑嗅觉障碍和味觉障碍是度洛西汀的不良反应。停用度洛西汀后，尽管继续服用其他正在进行的药物，但她的症状逐渐消退，上述检查结果有所改善。据我们所知，这是首例与度洛西汀相关的嗅觉障碍和味觉障碍的病例报告。
Common adverse effects of serotonin–norepinephrine reuptake inhibitors are nausea, dry mouth, dizziness and headache. We describe the case of a patient with dysosmia and subsequent dysgeusia associated with duloxetine. A 68-year-old Japanese woman with a history of type 1 diabetes mellitus, hypertension, insomnia and reflux esophagitis presented to a local hospital with bilateral leg pain; she was treated with duloxetine. However, after 4 weeks, she sensed rotten egg smell, experienced nausea and vomiting and was admitted to our hospital. We diagnosed dysosmia using the T&T olfactometer threshold test and dysgeusia using filter paper disk method. Taste was assessed using electrogustometry. We suspected that dysosmia and dysgeusia were adverse effects of duloxetine. After stopping duloxetine, her symptoms gradually subsided and the above test results improved, despite continuing the other ongoing medication. To the best of our knowledge, this is the first case report of dysosmia and dysgeusia associated with duloxetine.
氨氯地平味觉障碍——病例报告。
影响因子：
3.4
作者：
Balakrishnan Sadasivam;R. Jhaj
通讯作者：
R. Jhaj
药物引起的味觉和嗅觉障碍
影响因子：
4.1
作者：
B. Ackerman;N. Kasbekar
通讯作者：
N. Kasbekar
药物引起的味觉和嗅觉改变
影响因子：
4.2
作者：
M. Tuccori;F. Lapi;A. Testi;E. Ruggiero;U. Moretti;A. Vannacci;R. Bonaiuti;L. Antonioli;M. Fornai;G. Giustarini;C. Scollo;T. Corona;F. Ferrazin;L. Sottosanti;C. Blandizzi
通讯作者：
C. Blandizzi