DNA methylation as a mediator of the association between prenatal adversity and risk factors for metabolic disease in adulthood.
DNA methylation as a mediator of the association between prenatal adversity and risk factors for metabolic disease in adulthood.
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DOI：
10.1126/sciadv.aao4364
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发表时间：
2018-01
期刊：
影响因子：
13.6
通讯作者：
Heijmans BT
中科院分区：
文献类型：
--
作者：
Tobi EW;Slieker RC;Luijk R;Dekkers KF;Stein AD;Xu KM;Biobank-based Integrative Omics Studies Consortium;Slagboom PE;van Zwet EW;Lumey LH;Heijmans BT
DNA methylation mediates the association of prenatal famine exposure with higher adult BMI and serum triglyceride levels. Although it is assumed that epigenetic mechanisms, such as changes in DNA methylation (DNAm), underlie the relationship between adverse intrauterine conditions and adult metabolic health, evidence from human studies remains scarce. Therefore, we evaluated whether DNAm in whole blood mediated the association between prenatal famine exposure and metabolic health in 422 individuals exposed to famine in utero and 463 (sibling) controls. We implemented a two-step analysis, namely, a genome-wide exploration across 342,596 cytosine-phosphate-guanine dinucleotides (CpGs) for potential mediators of the association between prenatal famine exposure and adult body mass index (BMI), serum triglycerides (TG), or glucose concentrations, which was followed by formal mediation analysis. DNAm mediated the association of prenatal famine exposure with adult BMI and TG but not with glucose. DNAm at PIM3 (cg09349128), a gene involved in energy metabolism, mediated 13.4% [95% confidence interval (CI), 5 to 28%] of the association between famine exposure and BMI. DNAm at six CpGs, including TXNIP (cg19693031), influencing β cell function, and ABCG1 (cg07397296), affecting lipid metabolism, together mediated 80% (95% CI, 38.5 to 100%) of the association between famine exposure and TG. Analyses restricted to those exposed to famine during early gestation identified additional CpGs mediating the relationship with TG near PFKFB3 (glycolysis) and METTL8 (adipogenesis). DNAm at the CpGs involved was associated with gene expression in an external data set and correlated with DNAm levels in fat depots in additional postmortem data. Our data are consistent with the hypothesis that epigenetic mechanisms mediate the influence of transient adverse environmental factors in early life on long-term metabolic health. The specific mechanism awaits elucidation.
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影响因子：
168.9
作者：
Dick, Katherine J.;Nelson, Christopher P.;Samani, Nilesh J.
通讯作者：
Samani, Nilesh J.
影响因子：
7
作者：
Imai, Kosuke;Keele, Luke;Tingley, Dustin
通讯作者：
Tingley, Dustin
影响因子：
3.7
作者：
Das M;Sha J;Hidalgo B;Aslibekyan S;Do AN;Zhi D;Sun D;Zhang T;Li S;Chen W;Srinivasan SR;Tiwari HK;Absher D;Ordovas JM;Berenson GS;Arnett DK;Irvin MR
通讯作者：
Irvin MR
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y
影响因子：
3.5
作者：
Demerath, Ellen W.;Guan, Weihua;Boerwinkle, Eric
通讯作者：
Boerwinkle, Eric