Selective serotonin reuptake inhibitors and dental implant failureA significant concern in elders?
Selective serotonin reuptake inhibitors and dental implant failureA significant concern in elders?
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DOI：
10.1111/ger.12287
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发表时间：
2017-12-01
期刊：
影响因子：
2
通讯作者：
Kolokythas, Antonia
中科院分区：
文献类型：
--
作者：
Gupta, Bhumija;Acharya, Aneesha;Kolokythas, Antonia
目的抑郁症是老年人群中一个非常普遍的健康问题。选择性血清素再摄取抑制剂 (SSRI) 是最常用的抗抑郁药物，且处方率不断增加。本报告旨在简要回顾目前关于 SSRI 对骨和牙种植体结果影响的认识。材料和方法对有关 SSRI 对骨代谢和牙种植体存活的影响的文献进行了广泛的回顾和总结。结果现有文献表明，5-羟色胺在骨代谢中发挥着重要作用，实验报告表明 SSRI 对骨代谢的多种途径产生不利影响。早期临床报告表明 SSRI 对牙种植体的存活率有不利影响。 SSRI药物的类型、剂量以及宿主相关的遗传和代谢因素可能是潜在的调节因素。关于老年群体的 SSRI 使用和牙种植体存活率的数据很少。结论由于老年人是高口腔康复和 SSRI 使用的高风险群体，临床医生应该意识到 SSRI 和牙种植体失败之间的潜在关联。针对老年群体的精心设计的研究对于了解 SSRI 使用对牙种植体预后的影响至关重要。
ObjectiveDepression is a significantly prevalent health concern in geriatric populations. Selective serotonin reuptake inhibitor drugs (SSRI) are the most commonly prescribed antidepressant agents, with increasing rates of prescription. The present report aimed to present a concise review of the current understanding regarding SSRI effects on bone and dental implant outcomes.Materials and methodsA broad-based review and summary of literature pertaining to the effects of SSRI on bone metabolism and on dental implant survival was performed.ResultsThe available literature indicates that serotonin plays a significant role in bone metabolism and experimental reports demonstrate adverse impacts of SSRI on multiple pathways of bone metabolism. Early clinical reports suggest detrimental effects of SSRI on dental implant survival. The type of SSRI drug, dosage and host-related genetic and metabolic factors could be potential modulating factors. There is a paucity of data regarding SSRI usage and dental implant survival specific to geriatric cohorts.ConclusionAs older individuals comprise a high-risk group for both high oral rehabilitation and SSRI use, clinicians should be aware the potential association between SSRI and dental implant failures. Well-designed investigations specific to geriatric cohorts are essential to understand the implications of SSRI use on dental implant prognosis.