Evidence of stimulation of glucagon secretion by alanine in the human fetus at term.
Evidence of stimulation of glucagon secretion by alanine in the human fetus at term.
复制标题
丙氨酸刺激足月人类胎儿胰高血糖素分泌的证据。
DOI：
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发表时间：
1973
影响因子：
5.8
通讯作者：
P. Felig
中科院分区：
文献类型：
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作者：
J. K. Wise;S. Lyall;R. Hendler;P. Felig
在分娩过程中，正常妇女静脉注射丙氨酸（0.15 gm/kg）导致脐静脉和母体胰高血糖素水平比对照组高150-170%。较高的脐静脉和母体葡萄糖浓度伴随着血浆胰高血糖素的升高。这些数据表明，足月的人胎儿α细胞对生氨刺激有反应。
ABSTRACT Intravenous administration of alanine (0.15 gm/kg) to normal women during labor resulted in umbilical vein and maternal glucagon levels which were 150–170% higher than in control subjects. Higher umbilical vein and maternal glucose concentrations accompanied the elevation in plasma glucagon. The data suggest that the human fetal alpha cell at term is responsive to aminogenic stimulation.