A synthetic superoxide dismutase/catalase mimetic EUK-207 mitigates radiation dermatitis and promotes wound healing in irradiated rat skin.
A synthetic superoxide dismutase/catalase mimetic EUK-207 mitigates radiation dermatitis and promotes wound healing in irradiated rat skin.
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DOI：
10.1038/jid.2012.410
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发表时间：
2013-04
影响因子：
6.5
通讯作者：
Lazarova, Zelmira
中科院分区：
文献类型：
--
作者：
Doctrow, Susan R.;Lopez, Argelia;Schock, Ashley M.;Duncan, Nathan E.;Jourdan, Megan M.;Olasz, Edit B.;Moulder, John E.;Fish, Brian L.;Maeder, Marylou;Lazar, Jozef;Lazarova, Zelmira
在发生辐射袭击或核事故时，皮肤将是暴露于辐射的第一道屏障，尽管皮肤损伤可能在暴露后数天至数年内进展。慢性氧化应激被认为是皮肤和其他器官延迟辐射损伤进展的潜在促成因素。为了研究氧化应激在延迟性辐射诱导的皮肤损伤（包括伤口愈合受损）中的致病作用，我们在皮肤辐射和伤口损伤联合的大鼠模型中测试了合成的超氧化物歧化酶（SOD）/过氧化氢酶模拟物EUK-207。在照射后48小时开始全身给药，EUK-207减轻了放射性皮炎，抑制了组织氧化应激指标，并增强了伤口愈合。暴露后30天，对辐照皮肤中基因表达的评估显示，参与活性氧和氮类解毒的几个关键基因显著上调。这种基因表达模式主要被EUK-207治疗逆转。这些结果表明，氧化应激在辐射引起的皮肤损伤的进展中起着关键作用，并且可以通过暴露后48小时给予适当的抗氧化化合物来减轻损伤。
In the event of a radionuclear attack or nuclear accident, the skin would be the first barrier exposed to radiation, though skin injury can progress over days to years following exposure. Chronic oxidative stress has been implicated as being a potential contributor to the progression of delayed radiation-induced injury to skin and other organs. To examine the causative role of oxidative stress in delayed radiation-induced skin injury, including impaired wound healing, we tested a synthetic superoxide dismutase (SOD)/catalase mimetic, EUK-207, in a rat model of combined skin irradiation and wound injury. Administered systemically, beginning 48 h after irradiation, EUK-207 mitigated radiation dermatitis, suppressed indicators of tissue oxidative stress, and enhanced wound healing. Evaluation of gene expression in irradiated skin at 30 days after exposure revealed a significant upregulation of several key genes involved in detoxication of reactive oxygen and nitrogen species. This gene expression pattern was primarily reversed by EUK-207 therapy. These results demonstrate that oxidative stress plays a critical role in the progression of radiation-induced skin injury, and that the injury can be mitigated by appropriate antioxidant compounds administered 48 h after exposure.
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影响因子：
3.4
作者：
Jourdan, M. M.;Lopez, A.;Lazarova, Z.
通讯作者：
Lazarova, Z.
影响因子：
4.8
作者：
Handy, Diane E.;Lubos, Edith;Loscalzo, Joseph
通讯作者：
Loscalzo, Joseph
影响因子：
2.6
作者：
Mahmood J;Jelveh S;Calveley V;Zaidi A;Doctrow SR;Hill RP
通讯作者：
Hill RP
影响因子：
3.4
作者：
Aykin-Burns N;Slane BG;Liu AT;Owens KM;O'Malley MS;Smith BJ;Domann FE;Spitz DR
通讯作者：
Spitz DR
DOI：
10.1097/01.ta.0000177674.55388.40
发表时间：
2005-09-01
影响因子：
--
作者：
Liu, X;Liu, JZ;Zhou, YG
通讯作者：
Zhou, YG