CELL-CYCLE DEPENDENT COUPLING OF THE CALCITONIN RECEPTOR TO DIFFERENT G-PROTEINS
CELL-CYCLE DEPENDENT COUPLING OF THE CALCITONIN RECEPTOR TO DIFFERENT G-PROTEINS
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DOI：
10.1126/science.1847755
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发表时间：
1991-03-01
期刊：
影响因子：
56.9
通讯作者：
BARON, R
中科院分区：
文献类型：
--
作者：
CHAKRABORTY, M;CHATTERJEE, D;BARON, R
降钙素是一种钙调节肽激素，结合位点在肾脏和骨骼以及中枢神经系统。在猪肾细胞系中研究了降钙素受体的信号转导机制，发现该激素调节钠泵。降钙素受体激活环腺苷单磷酸（cAMP）或蛋白激酶C （PKC）途径。这两种转导途径需要鸟苷三磷酸（GTP）结合蛋白（G蛋白）(分别是胆曲霉毒素敏感的G(s)和百日咳毒素敏感的G(i))，并导致相反的生物学反应。此外，一种或另一种途径的选择性激活依赖于细胞周期。因此，根据靶细胞在细胞周期中的位置不同，降钙素可在靶细胞中诱导不同的生物学反应。这种配体诱导反应的调节在胚胎发生、生长和肿瘤形成等快速生长的细胞群中可能是重要的。
Calcitonin is a calcium regulating peptide hormone with binding sites in kidney and bone as well as in the central nervous system. The mechanisms of signal transduction by calcitonin receptors were studied in a pig kidney cell line where the hormone was found to regulate sodium pumps. Calcitonin receptors activated the cyclic adenosine monophosphate (cAMP) or the protein kinase C (PKC) pathways. The two transduction pathways required guanosine triphosphate (GTP)-binding proteins (G proteins) (the choleratoxin sensitive G(s) and the pertussis toxin sensitive G(i), respectively) and led to opposite biological responses. Moreover, selective activation of one or the other pathway was cell cycle-dependent. Therefore, calcitonin may induce different biological responses in target cells depending on their positions in the cell cycle. Such a modulation of ligand-induced responses could be of importance in rapidly growing cell populations such as during embryogenesis, growth, and tumor formation.