Stem and Progenitor Cell-Derived Astroglia Therapies for Neurological Diseases.
Stem and Progenitor Cell-Derived Astroglia Therapies for Neurological Diseases.
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DOI：
10.1016/j.molmed.2015.09.003
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发表时间：
2015-11
影响因子：
13.6
通讯作者：
Jiang P
中科院分区：
文献类型：
--
作者：
Chen C;Chan A;Wen H;Chung SH;Deng W;Jiang P
星形胶质细胞是中枢神经系统（CNS）的主要细胞组成部分，在脑发育、功能和完整性中起着至关重要的作用。越来越多的证据表明，星形胶质细胞功能障碍发生在各种神经系统疾病，从中枢神经系统损伤到遗传性疾病和慢性退行性疾病。这些新的见解预示着星形胶质细胞移植在治疗受损或患病的CNS中可能具有治疗价值的概念。从干细胞和祖细胞产生人类星形胶质细胞的最新技术进展已经突出。我们建议，更好地了解星形胶质细胞移植的适用性，以及它们在动物模型中的治疗效果，可能会导致建立基于星形胶质细胞的治疗方法来治疗神经系统疾病。
Astroglia are a major cellular constituent of the central nervous system (CNS) and play crucial roles in brain development, function and integrity. Increasing evidence demonstrates that astroglia dysfunction occurs in a variety of neurological disorders ranging from CNS injuries to genetic diseases and chronic degenerative conditions. These new insights herald the concept that transplantation of astroglia could be of therapeutic value in treating the injured or diseased CNS. Recent technological advances in the generation of human astroglia from stem and progenitor cells have been prominent. We propose that a better understanding of the suitability of astroglial cells in transplantation, as well as of their therapeutic effects in animal models may lead to the establishment of astroglia-based therapies to treat neurological diseases.