K27-linked noncanonic ubiquitination in immune regulation
K27-linked noncanonic ubiquitination in immune regulation
复制标题
K27 连接的非经典泛素化在免疫调节中的作用
DOI：
10.1002/jlb.4ru0620-397rr
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发表时间：
2022
影响因子：
5.5
通讯作者：
Zhang Jun
中科院分区：
文献类型：
--
作者：
Zhou Qingqing;Zhang Jun
泛素化是翻译后修饰的一种常见形式，与调节相当多的免疫信号通路有关。经典 K48 和 K63 连接泛素化的功能已得到充分研究。然而，非经典泛素化的作用在很大程度上仍未被探索，需要进一步研究。越来越多的证据表明，K27 相关的非经典泛素化对于先天免疫信号传导和 T 细胞信号传导都是不可或缺的。在这篇综述中，我们概述了与 K27 相关的泛素化相关的最新发现，并强调了 K27 相关的泛素化在调节抗菌反应、细胞因子信号传导和反应以及 T 细胞活化和分化中的关键作用。我们还提出了一些有趣的领域，以更好地了解 K27 相关的泛素化如何调节免疫。
Ubiquitination is a common form of posttranslational modification that has been implicated in regulating considerable immune signaling pathways. The functions of canonic K48- and K63-linked ubiquitination have been well studied. However, the roles of noncanonic ubiquitination remain largely unexplored and require further investigations. There is increasing evidence suggesting that K27-linked noncanonic ubiquitination turns out to be indispensable to both innate immune signaling and T cell signaling. In this review, we provide an overview of the latest findings related to K27-linked ubiquitination, and highlight the crucial roles of K27-linked ubiquitination in regulating antimicrobial response, cytokine signaling and response, as well as T cell activation and differentiation. We also propose interesting areas for better understanding how K27-linked ubiquitination regulates immunity.