Risk of malignancies in IgG4-related disease
Risk of malignancies in IgG4-related disease
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DOI：
10.3109/s10165-011-0520-x
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发表时间：
2012-06
影响因子：
2.2
通讯作者：
M. Yamamoto;H. Takahashi;T. Tabeya;C. Suzuki;Y. Naishiro;K. Ishigami;Hidetaka Yajima;Yui Shimizu;Mikiko Obara;Hiroyuki Yamamoto;T. Himi;K. Imai;Y. Shinomura
中科院分区：
文献类型：
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作者：
M. Yamamoto;H. Takahashi;T. Tabeya;C. Suzuki;Y. Naishiro;K. Ishigami;Hidetaka Yajima;Yui Shimizu;Mikiko Obara;Hiroyuki Yamamoto;T. Himi;K. Imai;Y. Shinomura
IgG4相关疾病（IgG4-RD）被认为是一种全身性、慢性炎症性疾病，其特征是受累器官肿大、IgG4水平升高、IgG4浆细胞大量浸润和受累器官纤维化。有必要将IgG4-RD与恶性肿瘤相鉴别。最近，我们查看了系统筛查中发现的 IgG4-RD 恶性肿瘤病例报告。在本研究中，我们分析了 IgG4-RD 与恶性肿瘤之间的关系。研究对象是自 1997 年 4 月以来转诊至我院的 106 名 IgG4-RD 患者。我们分析了 IgG4-RD 初次诊断时观察到的癌症或平均随访 3.1 年期间发生的癌症 IgG4-RD 患者的临床特征。利用监测日本癌症发病率的国家癌症登记处的数据，我们评估了 IgG4-RD 恶性肿瘤的标准化发病率 (SIR)。 11 名 IgG4-RD 患者（10.4%）观察到恶性肿瘤。这些恶性肿瘤各不相同，包括肺癌、结肠癌和淋巴瘤。除了 IgG4-RD 诊断的年龄之外，癌症患者和非癌症患者没有共同特征。这些恶性肿瘤的 IgG4-RD 的 SIR 为 383.0，高于一般人群。我们应该在诊断时和后续护理期间认识到 IgG4-RD 患者可能存在恶性肿瘤。
IgG4-related disease (IgG4-RD) is considered a systemic, chronic, and inflammatory disorder that is characterized by the enlargement of involved organs, elevated levels of IgG4, and abundant infiltration of plasmacytes with IgG4 and fibrosis in involved organs. It is necessary to differentiate IgG4-RD from malignant tumors. Recently we have looked at case reports of IgG4-RD with malignancy that was discovered at systemic screening. In this study, we analyzed the relationship between IgG4-RD and malignancies. The study subjects were 106 patients with IgG4-RD who had been referred to our hospital since April 1997. We analyzed the clinical characteristics of IgG4-RD patients who had cancer that was observed upon the initial diagnosis of IgG4-RD or that occurred during an average follow-up period of 3.1 years. Using data from national cancer registries that monitor cancer incidence in Japan, we evaluated the standardized incidence ratio (SIR) for malignancies in IgG4-RD. Malignancies were observed in 11 of the IgG4-RD patients (10.4%). The malignancies were all different and included lung cancer, colon cancer, and lymphoma. With the exception of the age at which the IgG4-RD diagnosis was made, there were no common features in patients with cancer and those without. The SIR for these malignancies in IgG4-RD was 383.0, which was higher than that for the general population. We should be cognizant of the possible existence of malignancies in patients with IgG4-RD at the time of diagnosis and during follow-up care.