Synthesis of meta-Terphenyl-2,2"-diols by Anodic C-C Cross-Coupling Reactions
Synthesis of meta-Terphenyl-2,2"-diols by Anodic C-C Cross-Coupling Reactions
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DOI：
10.1002/anie.201605865
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发表时间：
2016-08-26
影响因子：
16.6
通讯作者：
Waldvogel, Siegfried R.
中科院分区：
文献类型：
--
作者：
Lips, Sebastian;Wiebe, Anton;Waldvogel, Siegfried R.
阳极C-C交叉偶联反应是合成对称和非对称联苯酚和芳基化苯酚的一种通用方法。我们在此提出了一种无金属的电合成方法，该方法以良好的产率和高选择性提供了获得对称和非对称间-三联苯-2，2-二醇的途径。对称的衍生物可以通过在未分隔的电解槽中直接电解来获得。非对称间三联苯-2，2-二醇的合成需要两个电化学步骤。反应易于进行且可规模化。该方法还具有广泛的底物范围，并且容许多种官能团。靶分子可用作[OCO]（3-）钳形配体。
The anodic C-C cross-coupling reaction is a versatile synthetic approach to symmetric and non-symmetric biphenols and arylated phenols. We herein present a metal-free electrosynthetic method that provides access to symmetric and non-symmetric meta-terphenyl-2,2-diols in good yields and high selectivity. Symmetric derivatives can be obtained by direct electrolysis in an undivided cell. The synthesis of non-symmetric meta-terphenyl-2,2-diols required two electrochemical steps. The reactions are easy to conduct and scalable. The method also features a broad substrate scope, and a large variety of functional groups are tolerated. The target molecules may serve as [OCO](3-) pincer ligands.